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2020

Functional potato bioactive peptide intensifies Nrf2-dependent antioxidant defense against renal damage in hypertensive rats

Tsai, B. C. K., Hsieh, D. J. Y., Lin, W. T., Tamilselvi, S., Day, C. H., Ho, T. J., Chang, R. L., Viswanadha, V. P., Kuo, C. H. & Huang, C. Y., Mar 2020, In : Food Research International. 129, 108862.

Research output: Contribution to journalArticle

Solanum tuberosum
Antioxidants
antioxidant activity
hypertension
kidneys

LPS-enhanced IGF-IIR pathway to induce H9c2 cardiomyoblast cell hypertrophy was attenuated by Carthamus tinctorius extract via IGF-IR activation

Tung, C. L., Hsieh, D. J. Y., Baskaran, R., Ban, B., Dung, T. D., Ju, D. T., Viswanadha, V. P., Day, C. H., Yeh, Y. L. & Huang, C. Y., Feb 1 2020, In : Environmental Toxicology. 35, 2, p. 145-151 7 p.

Research output: Contribution to journalArticle

Carthamus tinctorius
IGF Type 2 Receptor
peptide
Hypertrophy
Small Interfering RNA

Protective effects of galangin against H2O2-induced aging via the IGF-1 signaling pathway in human dermal fibroblasts

Wen, S. Y., Chen, J. Y., Chen, C. J., Huang, C. Y. & Kuo, W. W., Feb 1 2020, In : Environmental Toxicology. 35, 2, p. 115-123 9 p.

Research output: Contribution to journalArticle

Fibroblasts
Insulin-Like Growth Factor I
Aging of materials
Skin
skin

Textile fabricated biodegradable composite stents with core-shell structure

Lin, M. C., Lin, J. H., Huang, C. Y. & Chen, Y. S., Jan 2020, In : Polymer Testing. 81, 106166.

Research output: Contribution to journalArticle

Stents
Textiles
Composite materials
Polyethylene glycols
Yarn
2019
1 Citation (Scopus)

Alpinate Oxyphyllae extracts enhance the longevity and homing of mesenchymal stem cells and augment their protection against senescence in H9c2 cells

Chang, Y. M., Asokan Shibu, M., Tsai, C. T., Tsai, C. C., Lin, S. L., Chang, C. C., Viswanadha, V. P., Chen, R. J., Chang, J. H. M. & Huang, C. Y., Jul 2019, In : Journal of Cellular Physiology. 234, 7, p. 12042-12050 9 p.

Research output: Contribution to journalArticle

Stem cells
Mesenchymal Stromal Cells
Stem Cells
Doxorubicin
CXC Chemokines
1 Citation (Scopus)

Alpinia oxyphylla Miq extract ameliorates cardiac fibrosis associated with D-galactose induced aging in rats

Chang, Y. M., Tamilselvi, S., Lin, H. J., Tsai, C. C., Lin, Y. M., Day, C. H., Viswanadha, V. P., Chang, H. N., Kuo, W. W. & Huang, C-Y., Feb 1 2019, In : Environmental Toxicology. 34, 2, p. 172-178 7 p.

Research output: Contribution to journalArticle

Alpinia
Galactose
Rats
Fibrosis
Aging of materials

Applying WCACG modified process is beneficial on reduced door-to-balloon time of acute STEMI patients

Li, Q. W., Liu, X. J., Li, J. H., Zhang, G. Q., Chen, S. M., Huang, C. L., Qiu, M., Li, Y. L., Duan, P., Weng, Y. J., Zhang, X. Y. & Huang, C. Y., Jun 2019, In : BioMedicine (France). 9, 2, p. 24-29 6 p., 10.

Research output: Contribution to journalArticle

Open Access
Balloons
Cardiology
Hospitalization
Costs and Cost Analysis
Group Processes
1 Citation (Scopus)

Bioactive flavone fisetin attenuates hypertension associated cardiac hypertrophy in H9c2 cells and in spontaneously hypertension rats

Lin, K. H., Shibu, M. A., Peramaiyan, R., Chen, Y. F., Shen, C. Y., Hsieh, Y. L., Chen, R. J., Viswanadha, V. P., Kuo, W. W. & Huang, C. Y., Jan 2019, In : Journal of Functional Foods. 52, p. 212-218 7 p.

Research output: Contribution to journalArticle

flavone
Cardiomegaly
flavones
hypertrophy
hypertension
1 Citation (Scopus)

Bioactive peptide vhvv upregulates the long-term memory-related biomarkers in adult spontaneously hypertensive rats

Ju, D. T., Ashok Kumar, K., Kuo, W. W., Ho, T. J., Chang, R. L., Lin, W. T., Day, C. H., Viswanadha, V. V. P., Liao, P. H. & Huang, C. Y., Jun 2 2019, In : International journal of molecular sciences. 20, 12, 3069.

Research output: Contribution to journalArticle

Open Access
Long-Term Memory
biomarkers
Memory Disorders
Biomarkers
Inbred SHR Rats
1 Citation (Scopus)

Carthamus tinctorius L. extract activates insulin-like growth factor-I receptor signaling to inhibit FAS-death receptor pathway and suppress lipopolysaccharides-induced H9c2 cardiomyoblast cell apoptosis

Tung, C. L., Ju, D. T., Velmurugan, B. K., Ban, B., Dung, T. D., Hsieh, D. J. Y., P. Viswanadha, V., Day, C. H., Lin, Y. M. & Huang, C. Y., Dec 1 2019, In : Environmental Toxicology. 34, 12, p. 1320-1328 9 p.

Research output: Contribution to journalArticle

Carthamus tinctorius
Death Domain Receptors
IGF Type 1 Receptor
apoptosis
Lipopolysaccharides
4 Citations (Scopus)

Casticin inhibits human prostate cancer DU 145 cell migration and invasion via Ras/Akt/NF-κB signaling pathways

Lin, C. C., Chen, K. B., Tsai, C. H., Tsai, F. J., Huang, C. Y., Tang, C. H., Yang, J. S., Hsu, Y. M., Peng, S. F. & Chung, J. G., Jul 2019, In : Journal of Food Biochemistry. 43, 7, e12902.

Research output: Contribution to journalArticle

cell invasion
prostatic neoplasms
cell movement
Cell Movement
Prostatic Neoplasms
2 Citations (Scopus)

CHIP attenuates lipopolysaccharide-induced cardiac hypertrophy and apoptosis by promoting NFATc3 proteasomal degradation

Chao, C. N., Lai, C. H., Badrealam, K. F., Lo, J. F., Shen, C. Y., Chen, C. H., Chen, R. J., Viswanadha, V. P., Kuo, W. W. & Huang, C. Y., Nov 2019, In : Journal of Cellular Physiology. 234, 11, p. 20128-20138 11 p.

Research output: Contribution to journalArticle

HSC70 Heat-Shock Proteins
NFATC Transcription Factors
Cardiomegaly
Lipopolysaccharides
Apoptosis

Combinational treatment of all-trans retinoic acid (ATRA) and bisdemethoxycurcumin (BDMC)-induced apoptosis in liver cancer Hep3B cells

Huang, T. Y., Peng, S. F., Huang, Y. P., Tsai, C. H., Tsai, F. J., Huang, C. Y., Tang, C. H., Yang, J. S., Hsu, Y. M., Yin, M. C., Huang, W. W. & Chung, J. G., Jan 1 2019, (Accepted/In press) In : Journal of Food Biochemistry. e13122.

Research output: Contribution to journalArticle

liver neoplasms
retinoic acid
Liver Neoplasms
Tretinoin
hepatocytes
4 Citations (Scopus)

CXCL2/CXCR2 axis induces cancer stem cell characteristics in CPT-11-resistant LoVo colon cancer cells via Gαi-2 and Gαq/11

Chen, M. C., Baskaran, R., Lee, N. H., Hsu, H. H., Ho, T. J., Tu, C. C., Lin, Y. M., Viswanadha, V. P., Kuo, W. W. & Huang, C. Y., Jul 2019, In : Journal of Cellular Physiology. 234, 7, p. 11822-11834 13 p.

Research output: Contribution to journalArticle

irinotecan
Neoplastic Stem Cells
Stem cells
Colonic Neoplasms
Cells

Deep ocean minerals inhibit IL-6 and IGFIIR hypertrophic signaling pathways to attenuate diabetes-induced hypertrophy in rat hearts

Lu, C. H., Shen, C. Y., Hsieh, D. J. Y., Lee, C. Y., Chang, R. L., Ju, D. T., Pai, P. Y., Viswanadha, V. P., Ou, H. C. & Huang, C. Y., Jan 1 2019, In : Journal of Applied Physiology. 127, 2, p. 356-364 9 p.

Research output: Contribution to journalArticle

Seawater
Oceans and Seas
Hypertrophy
Minerals
Interleukin-6

Deep sea minerals ameliorate diabetic-induced inflammation via inhibition of TNFα signaling pathways

Lu, C. H., Ou, H. C., Day, C. H., Chen, H. I., Pai, P. Y., Lee, C. Y., Chen, R. J., Chang, R. L., PadmaViswanadha, V., Hsieh, D. J. Y. & Huang, C. Y., Jan 1 2019, (Accepted/In press) In : Environmental Toxicology.

Research output: Contribution to journalArticle

Seawater
Oceans and Seas
Minerals
deep sea
deep water
1 Citation (Scopus)

Design, Synthesis, and Structure-Activity Relationships of 1,2,3-Triazole Benzenesulfonamides as New Selective Leucine-Zipper and Sterile-α Motif Kinase (ZAK) Inhibitors

Yang, J., Shibu, M. A., Kong, L., Luo, J., Badrealamkhan, F., Huang, Y., Tu, Z. C., Yun, C. H., Huang, C. Y., Ding, K. & Lu, X., Jan 1 2019, In : Journal of Medicinal Chemistry.

Research output: Contribution to journalArticle

Leucine Zippers
Triazoles
Drug Discovery
Structure-Activity Relationship
Phosphotransferases
1 Citation (Scopus)

Detailed insight on β-adrenoceptors as therapeutic targets

Velmurugan, B. K., Baskaran, R. & Huang, C. Y., Sep 2019, In : Biomedicine and Pharmacotherapy. 117, 109039.

Research output: Contribution to journalReview article

Open Access
Adrenergic Receptors
G-Protein-Coupled Receptors
Ligands
Therapeutics
Biomarkers

Dipeptide IF prevents the effects of hypertension-induced Alzheimer's disease on long-term memory in the cortex of spontaneously hypertensive rats

Chang, Y. M., Ashok Kumar, K., Ju, D. T., Ho, T. J., Mahalakshmi, B., Lin, W. T., Day, C. H., Vijaya Padma, V., Liao, P. H. & Huang, C. Y., Jan 1 2019, (Accepted/In press) In : Environmental Toxicology.

Research output: Contribution to journalArticle

hypertension
Long-Term Memory
Dipeptides
Inbred SHR Rats
peptide

Effect of vasicinone against paraquat-induced mapk/p53-mediated apoptosis via the igf-1r/pi3k/akt pathway in a parkinson’s disease-associated sh-sy5y cell model

Ju, D. T., Sivalingam, K., Kuo, W. W., Ho, T. J., Chang, R. L., Chung, L. C., Hsuan Day, C., Viswanadha, V. P., Liao, P. H. & Huang, C. Y., Jul 2019, In : Nutrients. 11, 7, 1655.

Research output: Contribution to journalArticle

Open Access
Paraquat
paraquat
Parkinson disease
Parkinson Disease
apoptosis
1 Citation (Scopus)

ERK1/2 mediates the lipopolysaccharide-induced upregulation of FGF-2, uPA, MMP-2, MMP-9 and cellular migration in cardiac fibroblasts

Chen, L. C., Shibu, M. A., Liu, C. J., Han, C. K., Ju, D. T., Chen, P. Y., Viswanadha, V. P., Lai, C. H., Kuo, W. W. & Huang, C. Y., Jun 1 2019, In : Chemico-Biological Interactions. 306, p. 62-69 8 p.

Research output: Contribution to journalArticle

Plasminogen Activators
Matrix Metalloproteinase 2
Matrix Metalloproteinase 9
Urokinase-Type Plasminogen Activator
Fibroblast Growth Factor 2
1 Citation (Scopus)

Fisetin activates Hippo pathway and JNK/ERK/AP-1 signaling to inhibit proliferation and induce apoptosis of human osteosarcoma cells via ZAK overexpression

Fu, C. Y., Chen, M. C., Tseng, Y. S., Chen, M. C., Zhou, Z., Yang, J. J., Lin, Y. M., Viswanadha, V. P., Wang, G. & Huang, C. Y., Aug 2019, In : Environmental Toxicology. 34, 8, p. 902-911 10 p.

Research output: Contribution to journalArticle

MAP Kinase Signaling System
Fasteners
Transcription Factor AP-1
apoptosis
Osteosarcoma

FOXC1 Regulation of miR-31-5p confers oxaliplatin resistance by targeting LATS2 in colorectal cancer

Hsu, H. H., Kuo, W. W., Shih, H. N., Cheng, S. F., Yang, C. K., Chen, M. C., Tu, C. C., Viswanadha, V. P., Liao, P. H. & Huang, C. Y., Oct 2019, In : Cancers. 11, 10, 1576.

Research output: Contribution to journalArticle

Open Access
oxaliplatin
Colorectal Neoplasms
Phosphotransferases
Neoplasms
Drug Resistance
2 Citations (Scopus)

Ginsenoside Rg1 supplementation clears senescence-associated β-galactosidase in exercising human skeletal muscle

Wu, J., Saovieng, S., Cheng, I. S., Liu, T., Hong, S., Lin, C. Y., Su, I. C., Huang, C. Y. & Kuo, C. H., Oct 2019, In : Journal of Ginseng Research. 43, 4, p. 580-588 9 p.

Research output: Contribution to journalArticle

Galactosidases
Muscle
beta-Galactosidase
Skeletal Muscle
Placebos
5 Citations (Scopus)

Glucocerebroside reduces endothelial progenitor cell-induced angiogenesis

Lee, H. P., Wang, S. W., Wu, Y. C., Tsai, C. H., Tsai, F. J., Chung, J. G., Huang, C. Y., Yang, J. S., Hsu, Y. M., Yin, M. C., Li, T. M. & Tang, C. H., Jan 1 2019, In : Food and Agricultural Immunology. 30, 1, p. 1033-1045 13 p.

Research output: Contribution to journalArticle

Open Access
Glucosylceramides
angiogenesis
endothelial cells
stem cells
vascular endothelial growth factors
8 Citations (Scopus)

High-density lipoprotein ameliorates palmitic acid-induced lipotoxicity and oxidative dysfunction in H9c2 cardiomyoblast cells via ROS suppression

Wu, K. M., Hsu, Y. M., Ying, M. C., Tsai, F. J., Tsai, C. H., Chung, J. G., Yang, J. S., Tang, C. H., Cheng, L. Y., Su, P. H., Viswanadha, V. P., Kuo, W. W. & Huang, C. Y., May 28 2019, In : Nutrition and Metabolism. 16, 1, 36.

Research output: Contribution to journalArticle

Open Access
Palmitic Acid
HDL Lipoproteins
Cardiac Myocytes
Proto-Oncogene Proteins c-bcl-2
Fatty Acids

Inhibition of protein phosphatase 1 stimulates noncanonical ER stress eIF2α activation to enhance fisetin-induced chemosensitivity in HDAC inhibitor-resistant hepatocellular carcinoma cells

Liu, Y. S., Yu-Chun, C., Kuo, W. W., Chen, M. C., Hsu, H. H., Tu, C. C., Yeh, Y. L., Viswanadha, V. P., Liao, P. H. & Huang, C. Y., Jul 2019, In : Cancers. 11, 7, 918.

Research output: Contribution to journalArticle

Open Access
Protein Phosphatase 1
Endoplasmic Reticulum Stress
Histone Deacetylase Inhibitors
Hepatocellular Carcinoma
Apoptosis
3 Citations (Scopus)

Insulin-like growth factor II receptor-α is a novel stress-inducible contributor to cardiac damage underpinning doxorubicin-induced oxidative stress and perturbed mitochondrial autophagy

Pandey, S., Kuo, W. W., Shen, C. Y., Yeh, Y. L., Ho, T. J., Chen, R. J., Chang, R. L., Pai, P. Y., Viswanadha, V. P., Huang, C. Y. & Huang, C. Y., Aug 2019, In : American Journal of Physiology - Cell Physiology. 317, 2, p. C235-C243

Research output: Contribution to journalArticle

IGF Type 2 Receptor
Autophagy
Doxorubicin
Oxidative Stress
Mitochondrial Membrane Potential

KHC-4 inhibits β-catenin expression in prostate cancer cells

Huang, C. Y., Velmurugan, B. K., Chen, M. C., Day, C. H., Chien, W. S., Padma, V. V., Wu, H. C., Lin, T. H., Hsu, H. H. & Shen, C. H., Jul 4 2019, In : Biotechnic and Histochemistry. 94, 5, p. 374-380 7 p.

Research output: Contribution to journalArticle

Catenins
Prostatic Neoplasms
G2 Phase
Cell Nucleus
Phosphatidylinositol 3-Kinases
2 Citations (Scopus)

Luteolin: A natural flavonoid enhances the survival of HUVECs against oxidative stress by modulating AMPK/PKC pathway

Ou, H. C., Pandey, S., Hung, M. Y., Huang, S. H., Hsu, P. T., Day, C. H., Pai, P., Viswanadha, V. P., Kuo, W. W. & Huang, C. Y., Jan 1 2019, In : American Journal of Chinese Medicine. 47, 3, p. 541-557 17 p.

Research output: Contribution to journalArticle

Luteolin
AMP-Activated Protein Kinases
Human Umbilical Vein Endothelial Cells
Flavonoids
Oxidative Stress
1 Citation (Scopus)

Neferine and isoliensinine enhance ‘intracellular uptake of cisplatin’ and induce ‘ROS-mediated apoptosis’ in colorectal cancer cells – A comparative study

Manogaran, P., Beeraka, N. M., Huang, C. Y. & Vijaya Padma, V., Oct 2019, In : Food and Chemical Toxicology. 132, 110652.

Research output: Contribution to journalArticle

neferine
cisplatin
colorectal neoplasms
Cisplatin
Colorectal Neoplasms
2 Citations (Scopus)

Neferine suppresses diethylnitrosamine-induced lung carcinogenesis in Wistar rats

Sivalingam, K., Amirthalingam, V., Ganasan, K., Huang, C. Y. & Viswanadha, V. P., Jan 2019, In : Food and Chemical Toxicology. 123, p. 385-398 14 p.

Research output: Contribution to journalArticle

neferine
Diethylnitrosamine
carcinogenesis
Wistar Rats
Rats
2 Citations (Scopus)

Oral administration of alcalase potato protein hydrolysate-APPH attenuates high fat diet-induced cardiac complications via TGF-β/GSN axis in aging rats

Hu, W. S., Ting, W. J., Tamilselvi, S., Day, C. H., Wang, T., Chiang, W. D., Viswanadha, V. P., Yeh, Y. L., Lin, W. T. & Huang, C. Y., Jan 2019, In : Environmental Toxicology. 34, 1, p. 5-12 8 p.

Research output: Contribution to journalArticle

Gelsolin
Subtilisins
Protein Hydrolysates
High Fat Diet
Nutrition

Oral administration of green tea Epigallocatechin-3-gallate reduces oxidative stress and enhances restoration of cardiac function in diabetic rats receiving autologous transplantation of adipose-derived stem cells

Chen, T. S., Liou, S. Y., Lin, H. H., Hung, M. Y., Lin, C. C., Lin, Y. M., Lin, K. H., Padma, V. V., Yao, C. H., Kuo, W. W. & Huang, C. Y., Jan 1 2019, In : Archives of Physiology and Biochemistry.

Research output: Contribution to journalArticle

Autologous Transplantation
Tea
Oral Administration
Diabetes Mellitus
Oxidative Stress

Orally administered resveratrol enhances the therapeutic effect of autologous transplanted adipose-derived stem cells on rats with diabetic hepatopathy

Chen, T. S., Lai, C. H., Shen, C. Y., Pai, P. Y., Chen, R. J., PadmaViswanadha, V., Yang, C. K., Chen, M. C., Lin, Y. M. & Huang, C. Y., Jan 1 2019, (Accepted/In press) In : Biotechnic and Histochemistry.

Research output: Contribution to journalArticle

Therapeutic Uses
Diabetes Mellitus
Stem Cell Transplantation
Stem Cells
Oral Administration
3 Citations (Scopus)

Overexpression of IGF-IIRα regulates cardiac remodeling and aggravates high salt induced apoptosis and fibrosis in transgenic rats

Chang, R. L., Nithiyanantham, S., Kuo, W. W., Pai, P. Y., Chang, T. T., Lai, C. H., Chen, R. J., Vijaya Padma, V., Huang, C. Y. & Huang, C. Y., Feb 1 2019, In : Environmental Toxicology. 34, 2, p. 210-218 9 p.

Research output: Contribution to journalArticle

Transgenic Rats
apoptosis
Rats
Fibrosis
Salts

Pheretima aspergillum extract attenuates high-KCl-induced mitochondrial injury and pro-fibrotic events in cardiomyoblast cells

Huang, P. C., Shibu, M. A., Kuo, C. H., Han, C. K., Chen, Y. S., Lo, F. Y., Li, H., Viswanadha, V. P., Lai, C. H., Li, X. & Huang, C. Y., Aug 2019, In : Environmental Toxicology. 34, 8, p. 921-927 7 p.

Research output: Contribution to journalArticle

Apoptosis Regulatory Proteins
Powders
Toxicity
Fibrosis
Chemical activation
19 Citations (Scopus)

Plumbagin suppresses endothelial progenitor cell-related angiogenesis in vitro and in vivo

Lee, H. P., Chen, P. C., Wang, S. W., Fong, Y. C., Tsai, C. H., Tsai, F. J., Chung, J. G., Huang, C. Y., Yang, J. S., Hsu, Y. M., Li, T. M. & Tang, C. H., Jan 2019, In : Journal of Functional Foods. 52, p. 537-544 8 p.

Research output: Contribution to journalArticle

plumbagin
angiogenesis
endothelial cells
stem cells
Physiologic Neovascularization
1 Citation (Scopus)

Protective effect of autologous transplantation of resveratrol preconditioned adipose-derived stem cells in the treatment of diabetic liver dysfunction in rat model

Chen, T. S., Ju, D. T., Day, C. H., Yeh, Y. L., Chen, R. J., Viswanadha, V. P., Chang, R. L., Lin, Y. C., Yao, C. H. & Huang, C. Y., Sep 1 2019, In : Journal of Tissue Engineering and Regenerative Medicine. 13, 9, p. 1629-1640 12 p.

Research output: Contribution to journalArticle

Resveratrol
Autologous Transplantation
Stem cells
Liver
Rats
3 Citations (Scopus)

Protective effect of Fisetin against angiotensin II-induced apoptosis by activation of IGF-IR-PI3K-Akt signaling in H9c2 cells and spontaneous hypertension rats

Chen, Y. P., Sivalingam, K., Shibu, M. A., Peramaiyan, R., Day, C. H., Shen, C. Y., Lai, C. H., Chen, R. J., Viswanadha, V. P., Chen, Y. F. & Huang, C-Y., Apr 1 2019, In : Phytomedicine. 57, p. 1-8 8 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinases
Angiotensin II
Apoptosis
Hypertension
Cell Survival

Ramipril and resveratrol co-treatment attenuates RhoA/ROCK pathway-regulated early-stage diabetic nephropathy-associated glomerulosclerosis in streptozotocin-induced diabetic rats

Peng, X., Su, H., Liang, D., Li, J., Ting, W. J., Liao, S. C. & Huang, C. Y., Jul 2019, In : Environmental Toxicology. 34, 7, p. 861-868 8 p.

Research output: Contribution to journalArticle

Ramipril
diabetes
Diabetic Nephropathies
Streptozocin
Medical problems
1 Citation (Scopus)

Resveratrol increases stem cell function in the treatment of damaged pancreas

Chen, T. S., Kuo, C. H., Day, C. H., Pan, L. F., Chen, R. J., Chen, B. C., Padma, V. V., Lin, Y. M. & Huang, C. Y., Nov 2019, In : Journal of Cellular Physiology. 234, 11, p. 20443-20452 10 p.

Research output: Contribution to journalArticle

Stem cells
Pancreas
Stem Cells
Rats
Therapeutics
1 Citation (Scopus)

Roles of p38α and p38β mitogen-activated protein kinase isoforms in human malignant melanoma A375 cells

Wen, S. Y., Cheng, S. Y., Ng, S. C., Aneja, R., Chen, C. J., Huang, C. Y. & Kuo, W. W., Jan 1 2019, In : International journal of molecular medicine. 44, 6, p. 2123-2132 10 p.

Research output: Contribution to journalArticle

Open Access
p38 Mitogen-Activated Protein Kinases
Melanoma
Protein Isoforms
Skin Neoplasms
Galactosidases
2 Citations (Scopus)

ROS- and HIF1α-dependent IGFBP3 upregulation blocks IGF1 survival signaling and thereby mediates high-glucose-induced cardiomyocyte apoptosis

Huang, Y. T., Liu, C. H., Yang, Y. C., Aneja, R., Wen, S. Y., Huang, C. Y. & Kuo, W. W., Aug 2019, In : Journal of Cellular Physiology. 234, 8, p. 13557-13570 14 p.

Research output: Contribution to journalArticle

Cardiac Myocytes
Hyperglycemia
Carrier Proteins
Up-Regulation
Oxidative stress

Satellite cells depletion in exercising human skeletal muscle is restored by ginseng component Rg1 supplementation

Wu, J., Saovieng, S., Cheng, I. S., Jensen, J., Jean, W. H., Alkhatib, A., Kao, C. L., Huang, C. Y. & Kuo, C. H., Jul 2019, In : Journal of Functional Foods. 58, p. 27-33 7 p.

Research output: Contribution to journalArticle

Panax
skeletal muscle
Skeletal Muscle
exercise
Exercise
6 Citations (Scopus)

Soya-cerebroside reduces IL-1β-induced MMP-1 production in chondrocytes and inhibits cartilage degradation: implications for the treatment of osteoarthritis

Liu, S. C., Tsai, C. H., Wu, T. Y., Tsai, C. H., Tsai, F. J., Chung, J. G., Huang, C. Y., Yang, J. S., Hsu, Y. M., Yin, M. C., Wu, Y. C. & Tang, C. H., Jan 1 2019, In : Food and Agricultural Immunology. 30, 1, p. 620-632 13 p.

Research output: Contribution to journalArticle

Open Access
cerebrosides
Cerebrosides
interstitial collagenase
Matrix Metalloproteinase 1
chondrocytes

Synergistic cardiac pathological hypertrophy induced by high-salt diet in IGF-IIRα cardiac-specific transgenic rats

Chang, R. L., Nithiyanantham, S., Huang, C. Y., Pai, P. Y., Chang, T. T., Hu, L. C., Chen, R. J., VijayaPadma, V., Kuo, W. W. & Huang, C. Y., Jun 2019, In : PloS one. 14, 6, e0216285.

Research output: Contribution to journalArticle

Open Access
Transgenic Rats
Cardiomegaly
Nutrition
hypertrophy
Rats
3 Citations (Scopus)

Taiwanin C elicits apoptosis in arecoline and 4-nitroquinoline-1-oxide-induced oral squamous cell carcinoma cells and hinders proliferation via epidermal growth factor receptor/PI3K suppression

Tsai, C. Y., Fang, H. Y., Shibu, M. A., Lin, Y. M., Chou, Y. C., Chen, Y. H., Day, C. H., Shen, C. Y., Ban, B. & Huang, C. Y., Jun 2019, In : Environmental Toxicology. 34, 6, p. 760-767 8 p.

Research output: Contribution to journalArticle

Arecoline
4-Nitroquinoline-1-oxide
apoptosis
Phosphatidylinositol 3-Kinases
Epidermal Growth Factor Receptor

Taiwanin E Induces Cell Cycle Arrest and Apoptosis in Arecoline/4-NQO-Induced Oral Cancer Cells Through Modulation of the ERK Signaling Pathway

Wang, S. H., Wu, H. C., Badrealam, K. F., Kuo, Y. H., Chao, Y. P., Hsu, H. H., Bau, D. T., Viswanadha, V. P., Chen, Y. H., Lio, P. J., Chiang, C. J. & Huang, C. Y., Dec 17 2019, In : Frontiers in Oncology. 9, 1309.

Research output: Contribution to journalArticle

Open Access
Arecoline
MAP Kinase Signaling System
Mouth Neoplasms
Cell Cycle Checkpoints
Apoptosis

The combined inhibition of the CaMKIIδ and calcineurin signaling cascade attenuates IGF-IIR-induced cardiac hypertrophy

Chen, C. H., Lin, J. W., Huang, C. Y., Yeh, Y. L., Shen, C. Y., Badrealam, K. F., Ho, T. J., Padma, V. V., Kuo, W. W. & Huang, C. Y., Jan 1 2019, (Accepted/In press) In : Journal of Cellular Physiology. 235, 4, p. 3539-3547 9 p.

Research output: Contribution to journalArticle

Calcium-Calmodulin-Dependent Protein Kinase Type 2
Calcineurin
Cardiomegaly
Hypertrophy
Chemical activation