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2019

Association of Immunosuppression with Outcomes of Patients with Cutaneous Squamous Cell Carcinoma of the Head and Neck

Tam, S., Yao, C. M. K., Amit, M., Gajera, M., Luo, X., Treistman, R., Khanna, A., Aashiq, M., Nagarajan, P., Bell, D., El-Naggar, A., Migden, M., Wong, M., Glisson, B., Ferrarotto, R., Esmaeli, B., Rosenthal, D., Li, G., Weber, R. S., Myers, J. N. & 1 others, Gross, N. D., Jan 1 2019, (Accepted/In press) In : JAMA Otolaryngology - Head and Neck Surgery.

Research output: Contribution to journalArticle

Immunosuppression
Skin
Squamous Cell Carcinoma
Transplants
Survival
1 Citation (Scopus)
Phosphorylation
Serine
HEK293 Cells
Caenorhabditis elegans
Pathologic Processes
2 Citations (Scopus)

Dicer1 phosphomimetic promotes tumor progression and dissemination

Arya, N. K., Pant, V., Wasylishen, A., Rimel, B. J., Baseler, L., El-Naggar, A. K., Mutch, D. G., Goodfellow, P. J., Arur, S. & Lozano, G., Jan 1 2019, In : Cancer research. 79, 10, p. 2662-2668 7 p.

Research output: Contribution to journalArticle

Neoplasms
Phosphorylation
Germ-Line Mutation
Extracellular Signal-Regulated MAP Kinases
Serine
Ectopic Hormones
Acinar Cell Carcinoma
Cushing Syndrome
Adrenocorticotropic Hormone
Neoplasm Metastasis

Erratum: Epidermal Growth Factor Receptor (EGFR) is overexpressed in anaplastic thyroid cancer, and the EGFR inhibitor gefitinib inhibits the growth of anaplastic thyroid cancer (Clinical Cancer Research(2004)10(8594–602)Doi:10.1158/1078-0432.CCR-04-0690)

Schiff, B. A., McMurphy, A. B., Jasser, S. A., Youne, M. N., Doan, D., Yigitbasi, O. G., Kim, S., Zhou, G., Mandal, M., Bekele, B. N., Holsinger, FC. C., Sherman, S. I., Yeung, S. C., El-Naggar, A. K. & Myers, J. N., Aug 1 2019, In : Clinical Cancer Research. 25, 15, 1 p.

Research output: Contribution to journalComment/debate

Open Access
Epidermal Growth Factor Receptor
Actins
Growth
Research
Neoplasms
Open Access
Insulin-Like Growth Factor Binding Protein 3
Transferases
Western Blotting
Research
Neoplasms
1 Citation (Scopus)

Genetic hallmarks of recurrent/metastatic adenoid cystic carcinoma

Ho, A. S., Ochoa, A., Jayakumaran, G., Zehir, A., Valero Mayor, C., Tepe, J., Makarov, V., Dalin, M. G., He, J., Bailey, M., Montesion, M., Ross, J. S., Miller, V. A., Chan, L., Ganly, I., Dogan, S., Katabi, N., Tsipouras, P., Ha, P., Agrawal, N. & 9 others, Solit, D. B., Futreal, P. A., El Naggar, A. K., Reis-Filho, J. S., Weigelt, B., Ho, A. L., Schultz, N., Chan, T. A. & Morris, L. G. T., Oct 1 2019, In : Journal of Clinical Investigation. 129, 10, p. 4276-4289 14 p.

Research output: Contribution to journalArticle

Open Access
Adenoid Cystic Carcinoma
Genetic Heterogeneity
Neoplasms
Mutation
Chromatin Assembly and Disassembly
6 Citations (Scopus)

GLIS Rearrangement is a Genomic Hallmark of Hyalinizing Trabecular Tumor of the Thyroid Gland

Nikiforova, M. N., Nikitski, A. V., Panebianco, F., Kaya, C., Yip, L., Williams, M. D., Chiosea, S. I., Seethala, R. R., Roy, S., Condello, V., Santana-Santos, L., Wald, A. I., Carty, S. E., Ferris, R. L., El-Naggar, A. K. & Nikiforov, Y. E., Feb 1 2019, In : Thyroid. 29, 2, p. 161-173 13 p.

Research output: Contribution to journalArticle

Thyroid Gland
Neoplasms
Collagen
Exome
Up-Regulation
Salivary Glands
Immunohistochemistry
Reverse Transcription
Carcinoma
Acinar Cell Carcinoma
2018
63 Citations (Scopus)

A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal

Rindi, G., Klimstra, D. S., Abedi-Ardekani, B., Asa, S. L., Bosman, F. T., Brambilla, E., Busam, K. J., de Krijger, R. R., Dietel, M., El-Naggar, A. K., Fernandez-Cuesta, L., Klöppel, G., McCluggage, W. G., Moch, H., Ohgaki, H., Rakha, E. A., Reed, N. S., Rous, B. A., Sasano, H., Scarpa, A. & 6 others, Scoazec, J. Y., Travis, W. D., Tallini, G., Trouillas, J., van Krieken, J. H. & Cree, I. A., Dec 1 2018, In : Modern Pathology. 31, 12, p. 1770-1786 17 p.

Research output: Contribution to journalArticle

International Agencies
Research
Neuroendocrine Tumors
Neoplasms
Carcinoid Tumor
1 Citation (Scopus)

Autoimmune Granulomatous Inflammation of Lacrimal Glands and Axonal Neuritis Following Treatment with Ipilimumab and Radiation Therapy

Dumbrava, E. I., Smith, V., Alfattal, R., El-Naggar, A. K., Penas-Prado, M. & Tsimberidou, A. M., Sep 1 2018, In : Journal of Immunotherapy. 41, 7, p. 336-339 4 p.

Research output: Contribution to journalArticle

Neuritis
Lacrimal Apparatus
CD274 Antigen
Radiotherapy
Inflammation
3 Citations (Scopus)

Contrasting effects of an Mdm2 functional polymorphism on tumor phenotypes

Ortiz, G. J., Li, Y., Post, S. M., Pant, V., Xiong, S., Larsson, C. A., El-Naggar, A. K., Johnson, D. G. & Lozano, G., Jan 18 2018, In : Oncogene. 37, 3, p. 332-340 9 p.

Research output: Contribution to journalArticle

Phenotype
Neoplasms
Alleles
Squamous Cell Carcinoma
Gastrin-Secreting Cells
3 Citations (Scopus)

Frequent and differential mutations of the CYLD gene in basal cell salivary neoplasms: linkage to tumor development and progression

Rito, M., Mitani, Y., Bell, D., Mariano, F. V., Almalki, S. T., Pytynia, K. B., Fonseca, I. & El-Naggar, A. K., Jul 1 2018, In : Modern Pathology. 31, 7, p. 1064-1072 9 p.

Research output: Contribution to journalArticle

Basal Cell Neoplasms
Mutation
Adenocarcinoma
Adenoma
Genes
5 Citations (Scopus)

Frequent PTEN loss and differential HER2/PI3K signaling pathway alterations in salivary duct carcinoma: Implications for targeted therapy

Saintigny, P., Mitani, Y., Pytynia, K. B., Ferrarotto, R., Roberts, D. B., Weber, R. S., Kies, M. S., Maity, S. N., Lin, S. H. & El-Naggar, A. K., Sep 15 2018, In : Cancer. 124, 18, p. 3693-3705 13 p.

Research output: Contribution to journalArticle

Salivary Ducts
1-Phosphatidylinositol 4-Kinase
Phosphoric Monoester Hydrolases
Carcinoma
Neoplasms
2 Citations (Scopus)

Incompletely treated malignancies of the major salivary gland: Toward evidence-based care

Tam, S., Sandulache, V. C., Metwalli, K. A., Rock, C. D., Eraj, S. A., Sheu, T., El-Naggar, A. K., Fuller, C., Weber, R. S. & Lai, S. Y., Aug 1 2018, In : Head and Neck. 40, 8, p. 1630-1638 9 p.

Research output: Contribution to journalArticle

Salivary Glands
Glandular and Epithelial Neoplasms
Survival
Neoplasms
Confidence Intervals
4 Citations (Scopus)
Perivascular Epithelioid Cell Neoplasms
Alveolar Soft Part Sarcoma
Oropharynx
Transcription Factors
Diagnostic Errors
3 Citations (Scopus)

Met Receptor Tyrosine Kinase and Chemoprevention of Oral Cancer

Saintigny, P., William, W. N., Foy, J. P., Papadimitrakopoulou, V., Lang, W., Zhang, L., Fan, Y. H., Feng, L., Kim, E. S., El-Naggar, A. K., Lee, J. J., Mao, L., Hong, W. K., Lingen, M. W. & Lippman, S. M., Mar 1 2018, In : Journal of the National Cancer Institute. 110, 3, djx186.

Research output: Contribution to journalArticle

Mouth Neoplasms
Chemoprevention
Receptor Protein-Tyrosine Kinases
Oral Leukoplakia
Cell Line
9 Citations (Scopus)

Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) in thyroid tumor classification

Kakudo, K., El-Naggar, A. K., Hodak, S. P., Khanafshar, E., Nikiforov, Y. E., Nosé, V. & Thompson, L. D. R., Jun 2018, In : Pathology International. 68, 6, p. 327-333 7 p.

Research output: Contribution to journalEditorial

Thyroid Neoplasms
Thyroid Gland
Neoplasms

PI3-kinase pathway biomarkers in oral cancer and tumor immune cells

Ibrahim, M. Y., Nunez, M. I., Harun, N., Lee, J. J., El-Naggar, A. K., Ferrarotto, R., Wistuba, I., Myers, J., Glisson, B. S. & William, W. N., Jan 1 2018, (Accepted/In press) In : Head and Neck.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Mouth Neoplasms
Biomarkers
Phosphoric Monoester Hydrolases
Squamous Cell Carcinoma
2 Citations (Scopus)

Somatic Trp53 mutations differentially drive breast cancer and evolution of metastases

Zhang, Y., Xiong, S., Liu, B., Pant, V., Celii, F., Chau, G., Elizondo-Fraire, A. C., Yang, P., You, M. J., El-Naggar, A. K., Navin, N. E. & Lozano, G., Dec 1 2018, In : Nature communications. 9, 1, 3953.

Research output: Contribution to journalArticle

metastasis
mutations
breast
Tumors
cancer
1 Citation (Scopus)

Synergistic and additive effect of retinoic acid in circumventing resistance to P53 restoration

Larsson, C. A., Moyer, S. M., Liu, B., Michel, K. A., Pant, V., Yang, P., Wong, J., El-Naggar, A. K., Krahe, R. & Lozano, G., Feb 27 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 9, p. 2198-2203 6 p.

Research output: Contribution to journalArticle

Tretinoin
Neoplasms
Lymphoma
Retinoids
Gene Expression Profiling
6 Citations (Scopus)

Transcriptomes define distinct subgroups of salivary gland adenoid cystic carcinoma with different driver mutations and outcomes

Frerich, C. A., Brayer, K. J., Painter, B. M., Kang, H., Mitani, Y., El-Naggar, A. K. & Ness, S. A., Jan 26 2018, In : Oncotarget. 9, 7, p. 7341-7358 18 p.

Research output: Contribution to journalArticle

Adenoid Cystic Carcinoma
Salivary Glands
Transcriptome
Mutation
Overlapping Genes
1 Citation (Scopus)

World Health Organization 4th edition of head and neck tumor classification: insight into the consequential modifications

Slootweg, P. J. & El-Naggar, A. K., Mar 1 2018, In : Virchows Archiv. 472, 3, p. 311-313 3 p.

Research output: Contribution to journalEditorial

Neck
Head
Neoplasms
2017

A 60-year-old woman with an asymptomatic left lacrimal gland mass found incidentally

Thakar, S. D., Sagiv, O., Tetzlaff, M. T., El-Naggar, A., Debnam, J. M., Kandl, T. J. & Esmaeli, B., Jan 1 2017, In : Digital journal of ophthalmology : DJO. 23, 4, p. 27-29 3 p.

Research output: Contribution to journalArticle

Lacrimal Apparatus
33 Citations (Scopus)

Activating NOTCH1 mutations define a distinct subgroup of patients with adenoid cystic carcinoma who have poor prognosis, propensity to bone and liver metastasis, and potential responsiveness to Notch1 inhibitors

Ferrarotto, R., Mitani, Y., Diao, L., Guijarro, I., Wang, J., Zweidler-McKay, P., Bell, D., William, W. N., Glisson, B. S., Wick, M. J., Kapoun, A. M., Patnaik, A., Eckhardt, G., Munster, P., Faoro, L., Dupont, J., Lee, J. J., Futreal, A., El-Naggar, A. K. & Heymach, J. V., Jan 20 2017, In : Journal of Clinical Oncology. 35, 3, p. 352-360 9 p.

Research output: Contribution to journalArticle

Adenoid Cystic Carcinoma
Neoplasm Metastasis
Bone and Bones
Mutation
Liver
3 Citations (Scopus)

Chromosomal abnormalities and molecular landscape of metastasizing mucinous salivary adenocarcinoma

Panaccione, A., Zhang, Y., Mi, Y., Yarbrough, W. G., Ivanov, S. V., Mitani, Y., El-Naggar, A. K., Yan, G., Prasad, M. L., McDonald, W. H., McDonald, W. H., El-Naggar, A. K., Yarbrough, W. G. & Yarbrough, W. G., Mar 1 2017, In : Oral Oncology. 66, p. 38-45 8 p.

Research output: Contribution to journalArticle

Mucinous Adenocarcinoma
Chromosome Aberrations
Proteomics
Neoplasms
Mutation
10 Citations (Scopus)
Mucoepidermoid Carcinoma
Neoplasms
Survival
Electronic Health Records
Salivary Glands
4 Citations (Scopus)
Nomograms
Laryngeal Neoplasms
Survival Analysis
Survival
Confidence Intervals
Neck
Head
Neoplasms
2 Citations (Scopus)

Establishment and genomic characterization of primary salivary duct carcinoma cell line

Li, J., Mitani, Y., Rao, P. H., Perlaky, L., Liu, B., Weber, R. S. & El-Naggar, A. K., Jun 1 2017, In : Oral Oncology. 69, p. 108-114 7 p.

Research output: Contribution to journalArticle

Salivary Ducts
Tumor Cell Line
Androgen Receptors
Carcinoma
Cell Line
9 Citations (Scopus)

Middle ear adenomatous neuroendocrine tumors: a 25-year experience at MD Anderson Cancer Center

Bell, D., El-Naggar, A. K. & Gidley, P. W., Nov 1 2017, In : Virchows Archiv. 471, 5, p. 667-672 6 p.

Research output: Contribution to journalArticle

Neuroendocrine Tumors
Middle Ear
Neoplasms
Pathology
Neuroendocrine Carcinoma
1 Citation (Scopus)

Mucoepidermoid carcinoma post−radioactive iodine treatment of papillary thyroid carcinoma: unique presentation and putative etiologic association

Saluja, K., Butler, R. T., Pytynia, K. B., Zhao, B., Karni, R. J., Weber, R. S. & El-Naggar, A. K., Oct 1 2017, In : Human Pathology. 68, p. 189-192 4 p.

Research output: Contribution to journalArticle

Mucoepidermoid Carcinoma
Iodine
Parotid Gland
Therapeutics
Phenotype
7 Citations (Scopus)

PD-1 blockade prevents the development and progression of carcinogen-induced oral premalignant lesions

Wang, J., Xie, T., Wang, B., William, W. N., Heymach, J. V., El-Naggar, A. K., Myers, J. N. & Caulin, C., Dec 1 2017, In : Cancer Prevention Research. 10, 12, p. 684-693 10 p.

Research output: Contribution to journalArticle

Death Domain Receptors
Carcinogens
Squamous Cell Carcinoma
T-Lymphocytes
4-Nitroquinoline-1-oxide

Prognostic biomarkers in patients with human immunodeficiency virus-positive disease with head and neck squamous cell carcinoma

on behalf of the Head and Neck Cancer SPORE HIV supplement consortium, Dec 2017, In : Head and Neck. 39, 12, p. 2433-2443 11 p.

Research output: Contribution to journalArticle

Virus Diseases
Head and Neck Neoplasms
Biomarkers
HIV
Tumor Biomarkers
20 Citations (Scopus)

Quality of Life and Performance Status From a Substudy Conducted Within a Prospective Phase 3 Randomized Trial of Concurrent Accelerated Radiation Plus Cisplatin With or Without Cetuximab for Locally Advanced Head and Neck Carcinoma: NRG Oncology Radiation Therapy Oncology Group 0522

Truong, M. T., Zhang, Q., Rosenthal, D. I., List, M., Axelrod, R., Sherman, E., Weber, R., Nguyen-Tân, P. F., El-Naggar, A., Konski, A., Galvin, J., Schwartz, D., Trotti, A., Silverman, C., Singh, A., Godette, K., Bonner, J. A., Jones, C. U., Garden, A. S., Shenouda, G. & 3 others, Matthiesen, C., Le, Q. T. & Bruner, D., Mar 15 2017, In : International Journal of Radiation Oncology Biology Physics. 97, 4, p. 687-699 13 p.

Research output: Contribution to journalArticle

Radiation Oncology
Head and Neck Neoplasms
Cisplatin
radiation therapy
Neck
13 Citations (Scopus)
Adenoid Cystic Carcinoma
Phylogeny
Neoplasms
Neoplasm Metastasis
Mutation
22 Citations (Scopus)

The fourth edition of the head and neck World Health Organization blue book: editors’ perspectives

El-Naggar, A. K., Chan, J. K. C., Takata, T., Grandis, J. R. & Slootweg, P. J., Aug 2017, In : Human Pathology. 66, p. 10-12 3 p.

Research output: Contribution to journalEditorial

Neck
Head
22 Citations (Scopus)

The KRAS-variant and cetuximab response in head and neck squamous cell cancer a secondary analysis of a randomized clinical trial

Weidhaas, J. B., Harris, J., Schaue, D., Chen, A. M., Chin, R., Axelrod, R., El-Naggar, A. K., Singh, A. K., Galloway, T. J., Raben, D., Wang, D., Matthiesen, C., Avizonis, V. N., Manon, R. R., Yumen, O., Nguyen-Tan, P. F., Trotti, A., Skinner, H., Zhang, Q., Ferris, R. L. & 2 others, Sidransky, D. & Chung, C. H., Jan 1 2017, In : JAMA Oncology. 3, 4, p. 483-491 9 p.

Research output: Contribution to journalArticle

Squamous Cell Neoplasms
Head and Neck Neoplasms
Randomized Controlled Trials
Head
Transforming Growth Factors
4 Citations (Scopus)
2016
79 Citations (Scopus)

An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma

Drier, Y., Cotton, M. J., Williamson, K. E., Gillespie, S. M., Ryan, R. J. H., Kluk, M. J., Carey, C. D., Rodig, S. J., Sholl, L. M., Afrogheh, A. H., Faquin, W. C., Queimado, L., Qi, J., Wick, M. J., El-Naggar, A. K., Bradner, J. E., Moskaluk, C. A., Aster, J. C., Knoechel, B. & Bernstein, B. E., Mar 1 2016, In : Nature Genetics. 48, 3, p. 265-272 8 p.

Research output: Contribution to journalArticle

Adenoid Cystic Carcinoma
Cell Lineage
Oncogenes
Chromatin
Neoplasms
9 Citations (Scopus)

Cdkn2a suppresses metastasis in squamous cell carcinomas induced by the gain-of-function mutant p53R172H

Li, Z., Gonzalez, C. L., Wang, B., Zhang, Y., Mejia, O., Katsonis, P., Lichtarge, O., Myers, J. N., El-Naggar, A. K. & Caulin, C., Oct 1 2016, In : Journal of Pathology. 240, 2, p. 224-234 11 p.

Research output: Contribution to journalArticle

Squamous Cell Carcinoma
Neoplasm Metastasis
Mutation
Neoplasms
Carcinoma

Cellular and molecular pathology of head and neck tumors

El-Naggar, A. K., Jan 1 2016, Head and Neck Cancer: Multimodality Management, Second Edition. Springer International Publishing, p. 77-99 23 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Molecular Pathology
Neck
Head
Neoplasms
Intermediate Filaments
9 Citations (Scopus)
Oropharyngeal Neoplasms
Radiation
Retrospective Studies
Therapeutics
Mucositis
9 Citations (Scopus)
Intensity-Modulated Radiotherapy
Nasopharynx
Carcinoma
Radiotherapy
Disease-Free Survival

Early detection and diagnosis of oral premalignant squamous mucosal lesions

Vigneswaran, N. & El-Naggar, A. K., Jan 1 2016, Biomedical Optics in Otorhinolaryngology: Head and Neck Surgery. Springer New York, p. 601-617 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Early Diagnosis
Squamous Cell Carcinoma
Mouth Neoplasms
Mouth
Neck
Local Neoplasm Recurrences
Thyroid Neoplasms
Carcinoma
Papillary Thyroid cancer
41 Citations (Scopus)

Erlotinib and the risk of oral cancer the erlotinib Prevention of Oral Cancer (EPOC) randomized clinical trial

William, W. N., Papadimitrakopoulou, V., Lee, J. J., Mao, L., Cohen, E. E. W., Lin, H. Y., Gillenwater, A. M., Martin, J. W., Lingen, M. W., Boyle, J. O., Shin, D. M., Vigneswaran, N., Shinn, N., Heymach, J. V., Wistuba, I. I., Tang, X., Kim, E. S., Saintigny, P., Blair, E. A., Meiller, T. & 4 others, Gutkind, J. S., Myers, J., El-Naggar, A. & Lippman, S. M., Jan 1 2016, In : JAMA Oncology. 2, 2, p. 209-216 8 p.

Research output: Contribution to journalArticle

Loss of Heterozygosity
Mouth Neoplasms
Randomized Controlled Trials
erbB-1 Genes
Gene Dosage

HPV and oropharyngeal cancer mystery: a glimmer of hope!

El-Naggar, A. K., Nov 1 2016, In : Oral Diseases. 22, 8, 1 p.

Research output: Contribution to journalComment/debate

Oropharyngeal Neoplasms