A breathless brake on ferroptosis

Mingchuang Sun; Li Zhuang; Boyi Gan

doi:10.1016/j.molcel.2025.07.008

A breathless brake on ferroptosis

Mingchuang Sun
, Li Zhuang
, Boyi Gan

Experimental Radiation Oncology

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

In this issue of Molecular Cell, Minikes et al.¹ reveal that hypoxia suppresses ferroptosis independently of HIF signaling via inhibition of the oxygen-sensitive histone demethylase KDM6A, linking hypoxia-mediated chromatin regulation to phospholipid metabolism and ferroptosis resistance in cancer.

Original language	English (US)
Pages (from-to)	2815-2817
Number of pages	3
Journal	Molecular cell
Volume	85
Issue number	15
DOIs	https://doi.org/10.1016/j.molcel.2025.07.008
State	Published - Aug 7 2025

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1016/j.molcel.2025.07.008

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@article{a059113efcdc401b8041cf421158478d,

title = "A breathless brake on ferroptosis",

abstract = "In this issue of Molecular Cell, Minikes et al.1 reveal that hypoxia suppresses ferroptosis independently of HIF signaling via inhibition of the oxygen-sensitive histone demethylase KDM6A, linking hypoxia-mediated chromatin regulation to phospholipid metabolism and ferroptosis resistance in cancer.",

author = "Mingchuang Sun and Li Zhuang and Boyi Gan",

note = "Publisher Copyright: {\textcopyright} 2025 Elsevier Inc.",

year = "2025",

month = aug,

day = "7",

doi = "10.1016/j.molcel.2025.07.008",

language = "English (US)",

volume = "85",

pages = "2815--2817",

journal = "Molecular cell",

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publisher = "Cell Press",

number = "15",

}

TY - JOUR

T1 - A breathless brake on ferroptosis

AU - Sun, Mingchuang

AU - Zhuang, Li

AU - Gan, Boyi

PY - 2025/8/7

Y1 - 2025/8/7

N2 - In this issue of Molecular Cell, Minikes et al.1 reveal that hypoxia suppresses ferroptosis independently of HIF signaling via inhibition of the oxygen-sensitive histone demethylase KDM6A, linking hypoxia-mediated chromatin regulation to phospholipid metabolism and ferroptosis resistance in cancer.

AB - In this issue of Molecular Cell, Minikes et al.1 reveal that hypoxia suppresses ferroptosis independently of HIF signaling via inhibition of the oxygen-sensitive histone demethylase KDM6A, linking hypoxia-mediated chromatin regulation to phospholipid metabolism and ferroptosis resistance in cancer.

UR - https://www.scopus.com/pages/publications/105012316643

UR - https://www.scopus.com/pages/publications/105012316643#tab=citedBy

U2 - 10.1016/j.molcel.2025.07.008

DO - 10.1016/j.molcel.2025.07.008

M3 - Comment/debate

C2 - 40780178

AN - SCOPUS:105012316643

SN - 1097-2765

VL - 85

SP - 2815

EP - 2817

JO - Molecular cell

JF - Molecular cell

IS - 15

ER -

A breathless brake on ferroptosis

Abstract

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