A Case of Diffuse Large B-Cell Lymphoma(DLBCL)Who Died of Acute Exacerbation of Interstitial Pneumonia after Treatment with R-mini-CHP in Combination with Polatuzumab Vedotin (Pola-R-mini-CHP)

84-year-old male was diagnosed with diffuse large B-cell lymphoma.He had Stage Ⅳ, performance status was 2, and 'high risk' according to the International Prognostic Index.He was started on Pola-R-mini-CHP.The day after completion of the 4 cycle, he developed shortness of breath, and we diagnosed he as having exacerbation of interstitial lung disease by CT.We started steroid pulse therapy.However, his condition failed to improve, and he died.An autopsy was performed.The pathological diagnosis was pulmonary fibrosis with acute diffuse alveolar damage.It is necessary to carefully monitor patients receiving Pola-R-CHP.