A chemical epitope-targeting strategy for protein capture agents: The serine 474 epitope of the kinase Akt2

Arundhati Nag; Samir Das; Mary Beth Yu; Kaycie M. Deyle; Steven W. Millward; James R. Heath

doi:10.1002/anie.201305882

A chemical epitope-targeting strategy for protein capture agents: The serine 474 epitope of the kinase Akt2

Arundhati Nag, Samir Das, Mary Beth Yu, Kaycie M. Deyle, Steven W. Millward, James R. Heath

Cancer Systems Imaging

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Target and click: Peptide ligands targeted to the C-terminal motif of the kinase Akt2 were obtained by combining phosphate recognition of a dinuclear zinc(II) complex with in situ click chemistry to target this epitope. The peptide ligands (shown as XXXXX) selectively bind the C-terminal polypeptide of Akt2, and are selective for Akt2 relative to the Akt1 and Akt3 isoforms. The ligands differentially modulate Akt2 activity.

Original language	English (US)
Pages (from-to)	13975-13979
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	52
DOIs	https://doi.org/10.1002/anie.201305882
State	Published - Dec 23 2013

Keywords

click chemistry
drug design
inhibitors
kinases
peptides

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.201305882

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AU - Millward, Steven W.

AU - Heath, James R.

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KW - drug design

KW - inhibitors

KW - kinases

KW - peptides

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A chemical epitope-targeting strategy for protein capture agents: The serine 474 epitope of the kinase Akt2

Abstract

Keywords

ASJC Scopus subject areas

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