Abstract
Target and click: Peptide ligands targeted to the C-terminal motif of the kinase Akt2 were obtained by combining phosphate recognition of a dinuclear zinc(II) complex with in situ click chemistry to target this epitope. The peptide ligands (shown as XXXXX) selectively bind the C-terminal polypeptide of Akt2, and are selective for Akt2 relative to the Akt1 and Akt3 isoforms. The ligands differentially modulate Akt2 activity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 13975-13979 |
| Number of pages | 5 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 52 |
| Issue number | 52 |
| DOIs | |
| State | Published - Dec 23 2013 |
Keywords
- click chemistry
- drug design
- inhibitors
- kinases
- peptides
ASJC Scopus subject areas
- Catalysis
- General Chemistry
Fingerprint
Dive into the research topics of 'A chemical epitope-targeting strategy for protein capture agents: The serine 474 epitope of the kinase Akt2'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS