TY - JOUR
T1 - A Contemporary Analysis of Surgical Trends in the Treatment of Squamous Cell Carcinoma of the Oropharynx from 1998 to 2012
T2 - A Report from the National Cancer Database
AU - Liederbach, Erik
AU - Lewis, Carol M.
AU - Yao, Katharine
AU - Brockstein, Bruce E.
AU - Wang, Chi Hsiung
AU - Lutfi, Waseem
AU - Bhayani, Mihir K.
N1 - Funding Information:
We thank the Auxillary of Evanston and Glenbrook Hospitals for their generous support of this project through the Research Fellowship program.
Publisher Copyright:
© 2015, Society of Surgical Oncology.
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Background: This study examined surgical trends for oropharynx squamous cell carcinoma (OPC) from 1998 to 2012, with a post-2009 focus coinciding with the Food and Drug Administration (FDA) approval of transoral robotic surgery (TORS). Methods: Using the National Cancer Data Base, the study analyzed 84,449 patients with stage I-IVB OPC. χ2 tests and logistic regression models were used to examine surgical trends. Results: The use of surgery decreased from 41.4 % in 1998 to 30.4 % in 2009 (p < 0.001). The surgical trends reversed and in 2012 increased to 34.8 % (p < 0.001). There was much variation in surgery in 2012 between American Joint Committee on Cancer stages, with 80.2 % of stage I patients receiving surgery compared with 54.0 % of stage II patients, 36.8 % of stage III patients, and 28.5 % of stage IV patients (p < 0.001). Black patients with high socioeconomic status (SES) showed lower use of surgery (25.3 %) compared to low SES white (32.3 %) and low SES Hispanic patients (27.3 %) (p < 0.001). The highest surgical rates were noted in the West North Central region and lowest rates were observed in the New England and South Atlantic regions. Between 2009 and 2012, independent predictors of surgical treatment included young age, female gender, white or Hispanic race, high SES, private insurance, academic hospitals, hospitals in the West North Central region, residence more than 75 miles from the hospital, increasing comorbidities, stage I disease, and tonsil origin (all p < 0.05). Conclusion: Since FDA approval of TORS in 2009, surgical rates have increased with multiple socioeconomic and regional factors affecting patient selection. This study provides a basis for further investigation into factors involved in decision making for OPC patients.
AB - Background: This study examined surgical trends for oropharynx squamous cell carcinoma (OPC) from 1998 to 2012, with a post-2009 focus coinciding with the Food and Drug Administration (FDA) approval of transoral robotic surgery (TORS). Methods: Using the National Cancer Data Base, the study analyzed 84,449 patients with stage I-IVB OPC. χ2 tests and logistic regression models were used to examine surgical trends. Results: The use of surgery decreased from 41.4 % in 1998 to 30.4 % in 2009 (p < 0.001). The surgical trends reversed and in 2012 increased to 34.8 % (p < 0.001). There was much variation in surgery in 2012 between American Joint Committee on Cancer stages, with 80.2 % of stage I patients receiving surgery compared with 54.0 % of stage II patients, 36.8 % of stage III patients, and 28.5 % of stage IV patients (p < 0.001). Black patients with high socioeconomic status (SES) showed lower use of surgery (25.3 %) compared to low SES white (32.3 %) and low SES Hispanic patients (27.3 %) (p < 0.001). The highest surgical rates were noted in the West North Central region and lowest rates were observed in the New England and South Atlantic regions. Between 2009 and 2012, independent predictors of surgical treatment included young age, female gender, white or Hispanic race, high SES, private insurance, academic hospitals, hospitals in the West North Central region, residence more than 75 miles from the hospital, increasing comorbidities, stage I disease, and tonsil origin (all p < 0.05). Conclusion: Since FDA approval of TORS in 2009, surgical rates have increased with multiple socioeconomic and regional factors affecting patient selection. This study provides a basis for further investigation into factors involved in decision making for OPC patients.
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U2 - 10.1245/s10434-015-4560-x
DO - 10.1245/s10434-015-4560-x
M3 - Article
C2 - 25893414
AN - SCOPUS:84947125536
SN - 1068-9265
VL - 22
SP - 4422
EP - 4431
JO - Annals of surgical oncology
JF - Annals of surgical oncology
IS - 13
ER -