A conveniently synthesized Pt (IV) conjugated alginate nanoparticle with ligand self-shielded property for targeting treatment of hepatic carcinoma

Xinyu Wang, Zhi Chang, Xin Nie, Yingying Li, Zhen Peng Hu, Jinlong Ma, Wei Wang, Teng Song, Pei Zhou, Huaqing Wang, Zhi Yuan

Research output: Contribution to journalArticle

Abstract

The clinical translation remains a major challenge for platinum drug loaded nanoparticle due to the complexity of composition and preparation. Here we employed only three ingredients to prepare Pt (IV) prodrug-loaded ligand-induced self-assembled nanoparticles (GA-ALG@Pt NPs) via facile one-pot route for liver tumor treatment. GA-ALG@Pt NPs were found equipped with intelligently ligand self-shielded property in which the internal GA could be induced to expose by initial cellular recognition, resulting in strengthened cellular uptake (20%-30%) and prolonged blood circulation time (3.43 times). Appreciable tumor targeting ability (2 times) and especially tumor selectivity (2.5 times) were obtained. Glutathione-triggered release of therapeutic agent generated satisfactory antitumor effect. Bio-safety is also a distinguishing feature of GA-ALG@Pt NPs that greatly relief the nephrotoxicity and systematic toxicity of cisplatin. This conveniently synthesized nanoparticle processes superior targeting capacity and biosecurity, supplying an effective approach to translational cancer therapy in the future.

LanguageEnglish (US)
Pages153-163
Number of pages11
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume15
Issue number1
DOIs
StatePublished - Jan 1 2019

Fingerprint

Glycyrrhetinic Acid
Cardiovascular system
Alginate
Cardiovascular System
Nanoparticles
Tumors
Ligands
Carcinoma
Liver
Neoplasms
Blood Circulation Time
Prodrugs
Hemodynamics
Platinum
Cisplatin
Glutathione
Toxicity
Chemical analysis
Safety
Pharmaceutical Preparations

Keywords

  • Glycyrrhetinic acid
  • Liver targeting
  • Pt (IV) prodrug
  • Self-shielded property

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Molecular Medicine
  • Biomedical Engineering
  • Materials Science(all)
  • Pharmaceutical Science

Cite this

A conveniently synthesized Pt (IV) conjugated alginate nanoparticle with ligand self-shielded property for targeting treatment of hepatic carcinoma. / Wang, Xinyu; Chang, Zhi; Nie, Xin; Li, Yingying; Hu, Zhen Peng; Ma, Jinlong; Wang, Wei; Song, Teng; Zhou, Pei; Wang, Huaqing; Yuan, Zhi.

In: Nanomedicine: Nanotechnology, Biology, and Medicine, Vol. 15, No. 1, 01.01.2019, p. 153-163.

Research output: Contribution to journalArticle

Wang, Xinyu ; Chang, Zhi ; Nie, Xin ; Li, Yingying ; Hu, Zhen Peng ; Ma, Jinlong ; Wang, Wei ; Song, Teng ; Zhou, Pei ; Wang, Huaqing ; Yuan, Zhi. / A conveniently synthesized Pt (IV) conjugated alginate nanoparticle with ligand self-shielded property for targeting treatment of hepatic carcinoma. In: Nanomedicine: Nanotechnology, Biology, and Medicine. 2019 ; Vol. 15, No. 1. pp. 153-163.
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