TY - JOUR
T1 - A cryptic BCR-PDGFRB fusion resulting in a chronic myeloid neoplasm with monocytosis and eosinophilia
T2 - Anovelfindingwithtreatmentimplications
AU - Gupta, Sanjeev Kumar
AU - Jain, Nitin
AU - Tang, Guilin
AU - Futreal, Andrew
AU - Wang, Sa A.
AU - Khoury, Joseph D.
AU - Yang, Richard K.
AU - Fang, Hong
AU - Patel, Keyur P.
AU - Luthra, Rajyalakshmi
AU - Routbort, Mark
AU - Barkoh, Bedia A.
AU - Chen, Wei
AU - Mao, Xizeng
AU - Zhang, Jianhua
AU - Jeffrey Medeiros, L.
AU - Bueso-Ramos, Carlos E.
AU - Loghavi, Sanam
N1 - Publisher Copyright:
© 2020 Harborside Press. All rights reserved.
PY - 2020/10
Y1 - 2020/10
N2 - RNA-seq was used to identify the partner gene and confirm the presence of a BCR-PDGFRB fusion. Identification of this fusion product resulted in successful treatment and long-term remission of this myeloid neoplasm. Based on our results, we suggest that despite current WHO recommendations, screening for PDGFRB rearrangement in cases of leukocytosis with eosinophilia and no other etiologic explanation is necessary, even if the karyotype is normal.
AB - RNA-seq was used to identify the partner gene and confirm the presence of a BCR-PDGFRB fusion. Identification of this fusion product resulted in successful treatment and long-term remission of this myeloid neoplasm. Based on our results, we suggest that despite current WHO recommendations, screening for PDGFRB rearrangement in cases of leukocytosis with eosinophilia and no other etiologic explanation is necessary, even if the karyotype is normal.
UR - http://www.scopus.com/inward/record.url?scp=85092319231&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85092319231&partnerID=8YFLogxK
U2 - 10.6004/jnccn.2020.7573
DO - 10.6004/jnccn.2020.7573
M3 - Article
C2 - 33022638
AN - SCOPUS:85092319231
SN - 1540-1405
VL - 18
SP - 1300
EP - 1304
JO - JNCCN Journal of the National Comprehensive Cancer Network
JF - JNCCN Journal of the National Comprehensive Cancer Network
IS - 10
ER -