@inproceedings{f8b8b6188c2749d796dbca7f6a01e661,
title = "A framework for optimizing micro-CT in dual-modality micro-CT/XFCT small-animal imaging system",
abstract = "Dual-modality Computed Tomography (CT)/X-ray Fluorescence Computed Tomography (XFCT) can be a valuable tool for imaging and quantifying the organ and tissue distribution of small concentrations of high atomic number materials in small-animal system. In this work, the framework for optimizing the micro-CT imaging system component of the dual-modality system is described, either when the micro-CT images are concurrently acquired with XFCT and using the x-ray spectral conditions for XFCT, or when the micro-CT images are acquired sequentially and independently of XFCT. This framework utilizes the cascaded systems analysis for task-specific determination of the detectability index using numerical observer models at a given radiation dose, where the radiation dose is determined using Monte Carlo simulations.",
keywords = "X-ray fluorescence computed tomography (XFCT), computed tomography (CT), small-animal imaging system",
author = "Srinivasan Vedantham and Suman Shrestha and Andrew Karellas and Cho, {Sang Hyun}",
note = "Publisher Copyright: {\textcopyright} COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.; Radiation Detectors in Medicine, Industry, and National Security XVIII 2017 ; Conference date: 09-08-2017 Through 10-08-2017",
year = "2017",
doi = "10.1117/12.2279351",
language = "English (US)",
series = "Proceedings of SPIE - The International Society for Optical Engineering",
publisher = "SPIE",
editor = "Grim, {Gary P.} and Furenlid, {Lars R.} and Barber, {H. Bradford}",
booktitle = "Radiation Detectors in Medicine, Industry, and National Security XVIII",
}