A Histomorphologic and Immunohistochemical Study of Chordoma in Twenty Ferrets (Mustela putorius furo)

D. G. Dunn, R. K. Harris, J. M. Meis, D. E. Sweet

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

The histomorphologic and immunohistochemical features of chordoma in 20 ferrets were evaluated. The mean age was 3.4 years, and, in the cases for which sex was known, females (n = 10) outnumbered males (n = 5) two to one. All 20 tumors occurred on the tip of the tail. Nineteen of 20 tumors (95%) were composed of three tissue components, often arranged concentrically with lobules of physaliferous cells at the periphery, trabecular bone in the center, and cartilage in between. The bone often contained marrow and hematopoietic cells. One tumor lacked chondromatous or osseous tissue. Immunohistochemical results were consistent with previous studies of chordoma. All 20 tumors (100%) were positive for keratin and vimentin intermediate filaments; 15 (75%) were positive for S-100 protein; and 17 (85%) were positive for neuron specific enolase. This neoplasm shares morphologic and immunohistochemical features with “classic,” as well as chon-droid chordoma, of human beings, making it a potential animal model.

Original languageEnglish (US)
Pages (from-to)467-473
Number of pages7
JournalVeterinary pathology
Volume28
Issue number6
DOIs
StatePublished - Nov 1991

Fingerprint

Chordoma
Ferrets
ferrets
neoplasms
Neoplasms
bones
Chondroma
intermediate filaments
phosphopyruvate hydratase
Intermediate Filaments
S100 Proteins
Phosphopyruvate Hydratase
keratin
vimentin
Vimentin
Keratins
cartilage
Cartilage
Tail
tail

ASJC Scopus subject areas

  • veterinary(all)

Cite this

A Histomorphologic and Immunohistochemical Study of Chordoma in Twenty Ferrets (Mustela putorius furo). / Dunn, D. G.; Harris, R. K.; Meis, J. M.; Sweet, D. E.

In: Veterinary pathology, Vol. 28, No. 6, 11.1991, p. 467-473.

Research output: Contribution to journalArticle

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