TY - JOUR
T1 - A Histomorphologic and Immunohistochemical Study of Chordoma in Twenty Ferrets (Mustela putorius furo)
AU - Dunn, D. G.
AU - Harris, R. K.
AU - Meis, J. M.
AU - Sweet, D. E.
PY - 1991/11
Y1 - 1991/11
N2 - The histomorphologic and immunohistochemical features of chordoma in 20 ferrets were evaluated. The mean age was 3.4 years, and, in the cases for which sex was known, females (n = 10) outnumbered males (n = 5) two to one. All 20 tumors occurred on the tip of the tail. Nineteen of 20 tumors (95%) were composed of three tissue components, often arranged concentrically with lobules of physaliferous cells at the periphery, trabecular bone in the center, and cartilage in between. The bone often contained marrow and hematopoietic cells. One tumor lacked chondromatous or osseous tissue. Immunohistochemical results were consistent with previous studies of chordoma. All 20 tumors (100%) were positive for keratin and vimentin intermediate filaments; 15 (75%) were positive for S-100 protein; and 17 (85%) were positive for neuron specific enolase. This neoplasm shares morphologic and immunohistochemical features with “classic,” as well as chon-droid chordoma, of human beings, making it a potential animal model.
AB - The histomorphologic and immunohistochemical features of chordoma in 20 ferrets were evaluated. The mean age was 3.4 years, and, in the cases for which sex was known, females (n = 10) outnumbered males (n = 5) two to one. All 20 tumors occurred on the tip of the tail. Nineteen of 20 tumors (95%) were composed of three tissue components, often arranged concentrically with lobules of physaliferous cells at the periphery, trabecular bone in the center, and cartilage in between. The bone often contained marrow and hematopoietic cells. One tumor lacked chondromatous or osseous tissue. Immunohistochemical results were consistent with previous studies of chordoma. All 20 tumors (100%) were positive for keratin and vimentin intermediate filaments; 15 (75%) were positive for S-100 protein; and 17 (85%) were positive for neuron specific enolase. This neoplasm shares morphologic and immunohistochemical features with “classic,” as well as chon-droid chordoma, of human beings, making it a potential animal model.
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U2 - 10.1177/030098589102800602
DO - 10.1177/030098589102800602
M3 - Article
C2 - 1722924
AN - SCOPUS:0026251239
SN - 0300-9858
VL - 28
SP - 467
EP - 473
JO - Veterinary pathology
JF - Veterinary pathology
IS - 6
ER -