TY - GEN
T1 - A Hoffman brain phantom lesion study with the transformable HOTPET camera
AU - Baghaei, Hossain
AU - Li, Hongdi
AU - Zhang, Yuxuan
AU - Ramirez, Rocio A.
AU - Liu, Shitao
AU - Wang, Chao
AU - An, Shaohui
AU - Wong, Wai Hoi
N1 - Copyright:
Copyright 2010 Elsevier B.V., All rights reserved.
PY - 2009
Y1 - 2009
N2 - The High-resolution Oncologic Transformable PET (HOTPET) camera has intrinsic spatial resolution of better than 3 mm and can operate in different modes including the whole-body mode and brain mode. In the whole-body mode, HOTPET has a transverse field-of-view (FOV) of 60 cm and an axial FOV of 13 cm. In the brain mode it has a transverse FOV of 39 cm and an axial FOV of 21 cm. The purpose of this study was to compare the performance of the two modes of HOTPET for studying small brain lesions (< 10 mm) to measure the effective gain in lesion detection by using a dedicated brain PET with higher sensitivity. We compared the two modes of camera by scanning the Hoffman brain phantom with three small lesion inserts for several lesion activity contrasts. The inner diameters of the lesion were in the range of 3.95 mm to 7.86 mm. The ratio of the activity concentration in the lesions to the activity in the background (gray matter regions) ranged from 1 to 20. Lesions were compared visually and also by measuring the contrast recovery and by studying their profiles. Visual inspection of the images showed that the 7.86-mm lesion with lesion to background activity ratio of 2 or higher was observable in both modes of the HOTPET. The 4.95-mm lesion was observable with lesion to background activity ratio of 4 (5.5) or higher in HOTPET brain (whole-body) mode. The 3.95-mm lesion was observable with lesion to background activity ratio of 8 (11) or higher in the brain (whole-body) mode. This study demonstrated the advantage of the brain mode of the HOTPET camera for detection of small lesions (<5 mm) compared to its whole-body mode and also compared to a simulated whole-body camera with crystals twice the average size of HOTPET's crystals.
AB - The High-resolution Oncologic Transformable PET (HOTPET) camera has intrinsic spatial resolution of better than 3 mm and can operate in different modes including the whole-body mode and brain mode. In the whole-body mode, HOTPET has a transverse field-of-view (FOV) of 60 cm and an axial FOV of 13 cm. In the brain mode it has a transverse FOV of 39 cm and an axial FOV of 21 cm. The purpose of this study was to compare the performance of the two modes of HOTPET for studying small brain lesions (< 10 mm) to measure the effective gain in lesion detection by using a dedicated brain PET with higher sensitivity. We compared the two modes of camera by scanning the Hoffman brain phantom with three small lesion inserts for several lesion activity contrasts. The inner diameters of the lesion were in the range of 3.95 mm to 7.86 mm. The ratio of the activity concentration in the lesions to the activity in the background (gray matter regions) ranged from 1 to 20. Lesions were compared visually and also by measuring the contrast recovery and by studying their profiles. Visual inspection of the images showed that the 7.86-mm lesion with lesion to background activity ratio of 2 or higher was observable in both modes of the HOTPET. The 4.95-mm lesion was observable with lesion to background activity ratio of 4 (5.5) or higher in HOTPET brain (whole-body) mode. The 3.95-mm lesion was observable with lesion to background activity ratio of 8 (11) or higher in the brain (whole-body) mode. This study demonstrated the advantage of the brain mode of the HOTPET camera for detection of small lesions (<5 mm) compared to its whole-body mode and also compared to a simulated whole-body camera with crystals twice the average size of HOTPET's crystals.
UR - https://www.scopus.com/pages/publications/77951202772
UR - https://www.scopus.com/pages/publications/77951202772#tab=citedBy
U2 - 10.1109/NSSMIC.2009.5401988
DO - 10.1109/NSSMIC.2009.5401988
M3 - Conference contribution
AN - SCOPUS:77951202772
SN - 9781424439621
T3 - IEEE Nuclear Science Symposium Conference Record
SP - 2674
EP - 2678
BT - 2009 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2009
T2 - 2009 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2009
Y2 - 25 October 2009 through 31 October 2009
ER -