A long non-coding RNA Lnc712 regulates breast cancer cell proliferation

Yue Cui, Chunxiao Lu, Zhiming Zhang, Aiqin Mao, Lei Feng, Li Fu, Feng Gu, Xin Ma, Dongxu He

Research output: Contribution to journalArticle

Abstract

Great quantity of intergenic noncoding RNAs (lncRNAs) have been identified in the mammalian genome and involved in various biological processes, especially in the development and metastasis of cancer. In this study, we identified one lncRNA, lncRNA NONHSAT028712 (Lnc712), was highly expressed in breast cancer cell lines and tissues based on microarray screening. Knockdown of Lnc712 largely inhibited breast cancer cell proliferation. Mechanistically, Lnc712 bound specifically to heat-shock protein 90 (HSP90). Interaction between Lnc712 and HSP90 is required for HSP90 binding to cell division cycle 37 (Cdc37). The Lnc712/HSP90/Cdc37 complex regulated cyclin-dependent kinase 2 (CDK2) activation and then triggered breast cancer cell proliferation. In summary, our results identified a new lncRNA regulate breast cancer proliferation though interaction with HSP90.

Original languageEnglish (US)
Pages (from-to)162-171
Number of pages10
JournalInternational journal of biological sciences
Volume16
Issue number1
DOIs
Publication statusPublished - Jan 1 2020

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Keywords

  • Breast Cancer
  • CDK2
  • HSP90
  • Long non-coding RNAs

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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