TY - JOUR
T1 - A Monte Carlo study of pinhole collimated Cerenkov luminescence imaging integrated with radionuclide treatment
AU - Geng, Changran
AU - Ai, Yao
AU - Tang, Xiaobin
AU - Shu, Diyun
AU - Gong, Chunhui
AU - Guan, Fada
N1 - Funding Information:
Funding This work was supported by the National Natural Science Foundation of China (Grant No. 11805100), and the National Key Research and Development Program (Grant No. 2016YFE0103600 and No. 2017YFC0107700).
Publisher Copyright:
© 2019, Australasian College of Physical Scientists and Engineers in Medicine.
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2019/6/15
Y1 - 2019/6/15
N2 - Cerenkov luminescence imaging (CLI) is an emerging optical imaging technique, which has been widely investigated for biological imaging. In this study, we proposed to integrate the CLI technique with the radionuclide treatment as a “see-and-treat” approach, and evaluated the performance of the pinhole collimator-based CLI technique. The detection of Cerenkov luminescence during radionuclide therapy was simulated using the Monte Carlo technique for breast cancer treatment as an example. Our results show that with the pinhole collimator-based configuration, the location, size and shape of the tumors can be clearly visualized on the Cerenkov luminescence images of the breast phantom. In addition, the CLI of multiple tumors can reflect the relative density of radioactivity among tumors, indicating that the intensity of Cerenkov luminescence is independent of the size and shape of a tumor. The current study has demonstrated the high-quality performance of the pinhole collimator-based CLI in breast tumor imaging for the “see-and-treat” multi-modality treatment.
AB - Cerenkov luminescence imaging (CLI) is an emerging optical imaging technique, which has been widely investigated for biological imaging. In this study, we proposed to integrate the CLI technique with the radionuclide treatment as a “see-and-treat” approach, and evaluated the performance of the pinhole collimator-based CLI technique. The detection of Cerenkov luminescence during radionuclide therapy was simulated using the Monte Carlo technique for breast cancer treatment as an example. Our results show that with the pinhole collimator-based configuration, the location, size and shape of the tumors can be clearly visualized on the Cerenkov luminescence images of the breast phantom. In addition, the CLI of multiple tumors can reflect the relative density of radioactivity among tumors, indicating that the intensity of Cerenkov luminescence is independent of the size and shape of a tumor. The current study has demonstrated the high-quality performance of the pinhole collimator-based CLI in breast tumor imaging for the “see-and-treat” multi-modality treatment.
KW - Breast tumor
KW - Cerenkov luminescence imaging
KW - Monte Carlo
KW - Radionuclide therapy
UR - http://www.scopus.com/inward/record.url?scp=85062796403&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85062796403&partnerID=8YFLogxK
U2 - 10.1007/s13246-019-00744-7
DO - 10.1007/s13246-019-00744-7
M3 - Article
C2 - 30830649
AN - SCOPUS:85062796403
SN - 0158-9938
VL - 42
SP - 481
EP - 487
JO - Australasian Physical and Engineering Sciences in Medicine
JF - Australasian Physical and Engineering Sciences in Medicine
IS - 2
ER -