Abstract
Ferroptosis is a cell death mechanism triggered by lipid peroxidation. Our recent study linked cyst(e)ine availability with glutathione peroxidase 4 (GPX4) protein synthesis and ferroptosis mitigation via a Rag-mechanistic target of rapamycin complex 1 (mTORC1) axis, and proposed that co-targeting mTORC1 and ferroptosis is a promising strategy for cancer therapy.
Original language | English (US) |
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Article number | 1919006 |
Journal | Molecular and Cellular Oncology |
Volume | 8 |
Issue number | 3 |
DOIs |
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State | Published - 2021 |
Keywords
- GPX4
- SLC7A11
- cancer therapy
- cysteine
- cystine
- ferroptosis
- lipid peroxidation
- mTORC1
ASJC Scopus subject areas
- Molecular Medicine
- Cancer Research