A mTORC1-mediated cyst(e)ine sensing mechanism governing GPX4 synthesis and ferroptosis

Yuelong Yan, Guang Lei, Boyi Gan

Research output: Contribution to journalComment/debatepeer-review

Abstract

Ferroptosis is a cell death mechanism triggered by lipid peroxidation. Our recent study linked cyst(e)ine availability with glutathione peroxidase 4 (GPX4) protein synthesis and ferroptosis mitigation via a Rag-mechanistic target of rapamycin complex 1 (mTORC1) axis, and proposed that co-targeting mTORC1 and ferroptosis is a promising strategy for cancer therapy.

Original languageEnglish (US)
Article number1919006
JournalMolecular and Cellular Oncology
Volume8
Issue number3
DOIs
StatePublished - 2021

Keywords

  • GPX4
  • SLC7A11
  • cancer therapy
  • cysteine
  • cystine
  • ferroptosis
  • lipid peroxidation
  • mTORC1

ASJC Scopus subject areas

  • Molecular Medicine
  • Cancer Research

Fingerprint

Dive into the research topics of 'A mTORC1-mediated cyst(e)ine sensing mechanism governing GPX4 synthesis and ferroptosis'. Together they form a unique fingerprint.

Cite this