A multicenter evaluation of near-infrared autofluorescence imaging of parathyroid glands in thyroid and parathyroid surgery

Ludovico Sehnem, Salem I. Noureldine, Seyma Avci, Gizem Isiktas, Mohammed Elshamy, Yoshiyuki Saito, Amr H.A. Ahmed, Hien T. Tierney, Lily N. Trinh, Amanda Silver Karcioglu, Anthony Y. Cheung, Michael Otremba, Vikram Krishnamurthy, Katherine Heiden, Judy Jin, Joyce Shin, Allan Siperstein, Mark Zafereo, Ralph P. Tufano, Gregory W. RandolphElectron Kebebew, Mira Milas, Quan yang Duh, Eren Berber

Research output: Contribution to journalArticlepeer-review


Background: The usefulness of incorporating near-infrared autofluorescence into the surgical workflow of endocrine surgeons is unclear. Our aim was to develop a prospective registry and gather expert opinion on appropriate use of this technology. Methods: This was a prospective multicenter collaborative study of patients undergoing thyroidectomy and parathyroidectomy at 7 academic centers. A questionnaire was disseminated among 24 participating surgeons. Results: Overall, 827 thyroidectomy and parathyroidectomy procedures were entered into registry: 42% of surgeons found near-infrared autofluorescence useful in identifying parathyroid glands before they became apparent; 67% correlated near-infrared autofluorescence pattern to normal and abnormal glands; 38% of surgeons used near-infrared autofluorescence, rather than frozen section, to confirm parathyroid tissue; and 87% and 78% of surgeons reported near-infrared autofluorescence did not improve the success rate after parathyroidectomy or the ability to find ectopic glands, respectively. During thyroidectomy, 66% of surgeons routinely used near-infrared autofluorescence to rule out inadvertent parathyroidectomy. However, only 36% and 45% felt near-infrared autofluorescence decreased inadvertent parathyroidectomy rates and improved ability to preserve parathyroid glands during central neck dissections, respectively. Conclusion: This survey study identified areas of greatest potential use for near-infrared autofluorescence, which can form the basis of future objective trials to document the usefulness of this technology.

Original languageEnglish (US)
Pages (from-to)132-137
Number of pages6
JournalSurgery (United States)
Issue number1
StatePublished - Jan 2023

ASJC Scopus subject areas

  • Surgery


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