Abstract
BRCA1 mediates homology-directed repair (HDR) of double-strand DNA breaks, explaining the sensitivity of BRCA1-deficient cancers to therapies that block DNA repair, while mutations that restore HDR cause therapy resistance. Research now reveals a mechanistically distinct vulnerability of BRCA1-deficient cancer cells to gap-inducing DNA nicks.
| Original language | English (US) |
|---|---|
| Article number | 1333 |
| Pages (from-to) | 234-236 |
| Number of pages | 3 |
| Journal | Nature Cancer |
| Volume | 6 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 2025 |
ASJC Scopus subject areas
- Oncology
- Cancer Research
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