A new look at Rho GTPases in cell cycle: Role in kinetochore-microtubule attachment

Shuh Narumiya, Fabian Oceguera-Yanez, Shingo Yasuda

    Research output: Contribution to journalReview article

    18 Scopus citations

    Abstract

    Rho GTPases including Rho, Rac and Cdc42 are involved in cell morphogenesis by inducing specific types of actin cytoskeleton and alignment and stabilization of microtubules. Previous studies suggest that they also regulate cell cycle progression; Rho, Rac and Cdc42 regulate the G1-S progression and Rho controls cytokinesis. However, a role of Rho GTPases in nuclear division has not been definitely shown. We have recently found that Cdc42 and its downstream effector mDia3 are involved in bi-orientation and stabilization of spindle microtubules attachment to kinetochores and regulate chromosome alignment and segregation. Here, we discuss how this is coordinated with other events in mitosis, particularly, with the action of Rho in cytokinesis and how attachment of microtubules to kinetochores is achieved and stabilized. We also discuss redundancy of Cdc42 and Cdc42-related GTPase(s) and potential mechanisms of chromosome instability in cancer.

    Original languageEnglish (US)
    Pages (from-to)853-855
    Number of pages3
    JournalCell Cycle
    Volume3
    Issue number7
    StatePublished - Jul 2004

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    Keywords

    • Actin
    • Cdc42
    • Chromosome alignment
    • Chromosome instability
    • GTPases
    • Kinetochore
    • Microtubules
    • Rho
    • Spindle checkpoint
    • mDia

    ASJC Scopus subject areas

    • Molecular Biology
    • Developmental Biology
    • Cell Biology

    Cite this

    Narumiya, S., Oceguera-Yanez, F., & Yasuda, S. (2004). A new look at Rho GTPases in cell cycle: Role in kinetochore-microtubule attachment. Cell Cycle, 3(7), 853-855.