Abstract
Background: Activating mutations of the receptor tyrosine kinase RET are associated with oncogenic function in medullary thyroid cancer. Results: RET is a dual specificity kinase phosphorylates ATF4, and inhibits expression of the ATF4 target proapoptotic genes. Conclusion: RET prevents apoptosis through inhibition of ATF4 activity. Significance Simultaneous targeting of RET and ATF4 may provide clinical benefit in cancers with RET abnormalities.
Original language | English (US) |
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Pages (from-to) | 11749-11761 |
Number of pages | 13 |
Journal | Journal of Biological Chemistry |
Volume | 290 |
Issue number | 18 |
DOIs | |
State | Published - May 1 2015 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology
MD Anderson CCSG core facilities
- Proteomics Facility