A novel dual kinase function of the RET proto-oncogene negatively regulates activating transcription factor 4-mediated apoptosis

Rozita Bagheri-Yarmand, Krishna M. Sinha, Anupama E. Gururaj, Zamal Ahmed, Yasmeen Q. Rizvi, Su Chen Huang, John E. Ladbury, Oliver Bogler, Michelle D. Williams, Gilbert J. Cote, Robert F. Gagel

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

Background: Activating mutations of the receptor tyrosine kinase RET are associated with oncogenic function in medullary thyroid cancer. Results: RET is a dual specificity kinase phosphorylates ATF4, and inhibits expression of the ATF4 target proapoptotic genes. Conclusion: RET prevents apoptosis through inhibition of ATF4 activity. Significance Simultaneous targeting of RET and ATF4 may provide clinical benefit in cancers with RET abnormalities.

Original languageEnglish (US)
Pages (from-to)11749-11761
Number of pages13
JournalJournal of Biological Chemistry
Volume290
Issue number18
DOIs
StatePublished - May 1 2015

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

MD Anderson CCSG core facilities

  • Proteomics Facility

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