A novel long non-coding RNA, Leat1, causes reduced anogenital distance and fertility in female mice

Deidre Mattiske, Richard R. Behringer, Paul A. Overbeek, Andrew J. Pask

Research output: Contribution to journalArticle

Abstract

Defective anorectal and urogenital malformations are some of the most severe congenital anomalies encountered in children. Only a few molecular cues have been identified in early formation of the female urogenital system. Here we describe a novel long non-coding RNA molecule known as Leat1 (long non-coding RNA, EphrinB2 associated transcript 1). This lncRNA is syntenic with EfnB2 (which encodes EphrinB2) and expressed during embryonic development of the genital tubercle. While lncRNAs have varied functions, many are known to regulate their neighbouring genes. Eph/Ephrin bidirectional signaling molecules mediate many patterning pathways in early embryonic development, including cloacal septation and urethral development. Here we investigate the role of Leat1 and its possible regulation of EphrinB2 during development of the female reproductive tract. We show that a loss of Leat1 leads to reduced EfnB2 expression in the developing female genital tubercle, reduced anogenital distance and decreased fertility.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalDifferentiation
Volume112
DOIs
StatePublished - Mar 1 2020

Fingerprint

Long Noncoding RNA
Fertility
Embryonic Development
Ephrins
Urogenital System
Cues
Genes

Keywords

  • Cloacal septation
  • Eph/ephrin
  • Female urogenital
  • lncRNA

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology
  • Cancer Research

Cite this

A novel long non-coding RNA, Leat1, causes reduced anogenital distance and fertility in female mice. / Mattiske, Deidre; Behringer, Richard R.; Overbeek, Paul A.; Pask, Andrew J.

In: Differentiation, Vol. 112, 01.03.2020, p. 1-6.

Research output: Contribution to journalArticle

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