A novel p38 MAPK docking-groove-targeted compound is a potent inhibitor of inflammatory hyperalgesia

Keyphrases

• Potent Inhibitor 100%
• P38 Mitogen-activated Protein Kinase (p38 MAPK) 100%
• Inflammatory Hyperalgesia 100%
• Targeted Compounds 100%
• Inhibitory Activity 40%
• Inflammatory Pain 40%
• Mouse Model 20%
• Tumor Necrosis Factor-α 20%
• Intrathecal Injection 20%
• Signal Transduction 20%
• Neuropathic Pain 20%
• IC50 Value 20%
• G Protein 20%
• Human Monocytes 20%
• Inflammatory Mediators 20%
• Lipopolysaccharide-induced 20%
• Hyperalgesia 20%
• Phenyl Ring 20%
• Lysozyme 20%
• THP1 20%
• MAPK Inhibitors 20%
• In Vivo Effects 20%
• GRK2 20%
• Virtual Screening 20%
• Chloride 20%
• Benzo 20%
• Analgesic Effect 20%
• Long-lasting Effect 20%
• Methyl Groups 20%
• Docking Site 20%
• Persistent Pain 20%
• Activity Assay 20%
• Oxadiazole 20%
• SB239063 20%
• Targeted Inhibitors 20%
• Post-inflammatory 20%

Medicine and Dentistry

• p38 Mitogen-Activated Protein Kinase 100%
• Hyperpathia 100%
• Inflammatory Pain 40%
• Intrathecal Drug Administration 20%
• IC50 20%
• Phosphotransferase 20%
• Neuropathic Pain 20%
• Mediator 20%
• Lipopolysaccharide 20%
• Mitogen Activated Protein Kinase P38 20%
• Guanine Nucleotide Binding Protein 20%
• Secretion (Process) 20%
• Tumor Necrosis 20%
• Signal Transduction 20%
• Lysozyme 20%
• Analgesic Activity 20%
• Virtual Screening 20%
• Persistent Pain 20%
• 4 [4 (4 Fluorophenyl) 5 (2 Methoxy 4 Pyrimidinyl) 1 Imidazolyl]cyclohexanol 20%
• Methyl Group 20%
• Inflammation 20%
• Monocyte 20%
• Chloride 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Hyperalgesia 100%
• Inflammatory Pain 50%
• Phosphotransferase 25%
• Mouse Model 25%
• Intrathecal 25%
• Analgesic Agent 25%
• IC50 25%
• Inflammation 25%
• Neuropathic Pain 25%
• Lipopolysaccharide 25%
• Mitogen Activated Protein Kinase P38 25%
• Guanine Nucleotide Binding Protein 25%
• Tumor Necrosis 25%
• Virtual Screening 25%
• Lysozyme 25%
• Methyl Group 25%
• 4 [4 (4 Fluorophenyl) 5 (2 Methoxy 4 Pyrimidinyl) 1 Imidazolyl]cyclohexanol 25%
• Chloride 25%