A novel scoring system based on hemostatic parameters predicts the prognosis of patients with advanced pancreatic cancer

Ke Zhang, Hui Feng Gao, Miao Mo, Cai Jun Wu, Yong Qiang Hua, Zheng Chen, Zhiqiang Meng, Luming Liu, Hao Chen

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: The aim of this study was to evaluate the prognostic value of pre-treatment plasma hemostatic parameters in patients with advanced pancreatic cancer. Methods: A total of 320 patients diagnosed with advanced pancreatic cancer between January 1, 2011 to December 31, 2015 were enrolled in this retrospective study. The prognostic significance of hemostatic parameters such as prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FBG), platelet count (PLT), mean platelet volume (MPV), plateletcrit (PCT), and platelet distribution width (PDW) was determined by univariate and multivariate Cox hazard models. Then, Kaplan-Meier methods and log-rank tests were performed to compare the survival of patients in different risk groups. Result: Univariate and multivariate analyses showed that prolonged PT, high FBG, and high MPV were independent prognostic factors for poor overall survival (PT > 11.3 s, HR = 1.46, 95%CI = 1.10–1.94, p = 0.009; FBG>2.5 g/L, HR = 1.41, 95%CI = 1.08–1.84, p = 0.011; MPV>12.2 fL, HR = 1.52, 95%CI = 1.13–2.04, p = 0.005). Moreover, all the patients were stratified into three groups by a scoring system based on these three hemostatic markers. The median survival time of the three groups was 8.8 months, 6.3 months and 4.3 months (P < 0.001). Conclusion: PT, FBG and MPV were independent prognostic factors in advanced pancreatic cancer. A novel scoring system based on these hemostatic parameters could be used to predict the survival of patients with advanced pancreatic cancer.

Original languageEnglish (US)
Pages (from-to)346-351
Number of pages6
JournalPancreatology
Volume19
Issue number2
DOIs
StatePublished - Mar 1 2019

Fingerprint

Mean Platelet Volume
Hemostatics
Pancreatic Neoplasms
Prothrombin Time
Fibrinogen
Survival
Proportional Hazards Models
Partial Thromboplastin Time
Platelet Count
Blood Platelets
Multivariate Analysis
Retrospective Studies

Keywords

  • Fibrinogen
  • Mean platelet volume
  • Pancreatic cancer
  • Prognosis
  • Prothrombin time

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Gastroenterology

Cite this

A novel scoring system based on hemostatic parameters predicts the prognosis of patients with advanced pancreatic cancer. / Zhang, Ke; Gao, Hui Feng; Mo, Miao; Wu, Cai Jun; Hua, Yong Qiang; Chen, Zheng; Meng, Zhiqiang; Liu, Luming; Chen, Hao.

In: Pancreatology, Vol. 19, No. 2, 01.03.2019, p. 346-351.

Research output: Contribution to journalArticle

Zhang, Ke ; Gao, Hui Feng ; Mo, Miao ; Wu, Cai Jun ; Hua, Yong Qiang ; Chen, Zheng ; Meng, Zhiqiang ; Liu, Luming ; Chen, Hao. / A novel scoring system based on hemostatic parameters predicts the prognosis of patients with advanced pancreatic cancer. In: Pancreatology. 2019 ; Vol. 19, No. 2. pp. 346-351.
@article{0fa513bbef154c6b94b6580db42e5483,
title = "A novel scoring system based on hemostatic parameters predicts the prognosis of patients with advanced pancreatic cancer",
abstract = "Objective: The aim of this study was to evaluate the prognostic value of pre-treatment plasma hemostatic parameters in patients with advanced pancreatic cancer. Methods: A total of 320 patients diagnosed with advanced pancreatic cancer between January 1, 2011 to December 31, 2015 were enrolled in this retrospective study. The prognostic significance of hemostatic parameters such as prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FBG), platelet count (PLT), mean platelet volume (MPV), plateletcrit (PCT), and platelet distribution width (PDW) was determined by univariate and multivariate Cox hazard models. Then, Kaplan-Meier methods and log-rank tests were performed to compare the survival of patients in different risk groups. Result: Univariate and multivariate analyses showed that prolonged PT, high FBG, and high MPV were independent prognostic factors for poor overall survival (PT > 11.3 s, HR = 1.46, 95{\%}CI = 1.10–1.94, p = 0.009; FBG>2.5 g/L, HR = 1.41, 95{\%}CI = 1.08–1.84, p = 0.011; MPV>12.2 fL, HR = 1.52, 95{\%}CI = 1.13–2.04, p = 0.005). Moreover, all the patients were stratified into three groups by a scoring system based on these three hemostatic markers. The median survival time of the three groups was 8.8 months, 6.3 months and 4.3 months (P < 0.001). Conclusion: PT, FBG and MPV were independent prognostic factors in advanced pancreatic cancer. A novel scoring system based on these hemostatic parameters could be used to predict the survival of patients with advanced pancreatic cancer.",
keywords = "Fibrinogen, Mean platelet volume, Pancreatic cancer, Prognosis, Prothrombin time",
author = "Ke Zhang and Gao, {Hui Feng} and Miao Mo and Wu, {Cai Jun} and Hua, {Yong Qiang} and Zheng Chen and Zhiqiang Meng and Luming Liu and Hao Chen",
year = "2019",
month = "3",
day = "1",
doi = "10.1016/j.pan.2018.12.010",
language = "English (US)",
volume = "19",
pages = "346--351",
journal = "Pancreatology",
issn = "1424-3903",
publisher = "S. Karger AG",
number = "2",

}

TY - JOUR

T1 - A novel scoring system based on hemostatic parameters predicts the prognosis of patients with advanced pancreatic cancer

AU - Zhang, Ke

AU - Gao, Hui Feng

AU - Mo, Miao

AU - Wu, Cai Jun

AU - Hua, Yong Qiang

AU - Chen, Zheng

AU - Meng, Zhiqiang

AU - Liu, Luming

AU - Chen, Hao

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Objective: The aim of this study was to evaluate the prognostic value of pre-treatment plasma hemostatic parameters in patients with advanced pancreatic cancer. Methods: A total of 320 patients diagnosed with advanced pancreatic cancer between January 1, 2011 to December 31, 2015 were enrolled in this retrospective study. The prognostic significance of hemostatic parameters such as prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FBG), platelet count (PLT), mean platelet volume (MPV), plateletcrit (PCT), and platelet distribution width (PDW) was determined by univariate and multivariate Cox hazard models. Then, Kaplan-Meier methods and log-rank tests were performed to compare the survival of patients in different risk groups. Result: Univariate and multivariate analyses showed that prolonged PT, high FBG, and high MPV were independent prognostic factors for poor overall survival (PT > 11.3 s, HR = 1.46, 95%CI = 1.10–1.94, p = 0.009; FBG>2.5 g/L, HR = 1.41, 95%CI = 1.08–1.84, p = 0.011; MPV>12.2 fL, HR = 1.52, 95%CI = 1.13–2.04, p = 0.005). Moreover, all the patients were stratified into three groups by a scoring system based on these three hemostatic markers. The median survival time of the three groups was 8.8 months, 6.3 months and 4.3 months (P < 0.001). Conclusion: PT, FBG and MPV were independent prognostic factors in advanced pancreatic cancer. A novel scoring system based on these hemostatic parameters could be used to predict the survival of patients with advanced pancreatic cancer.

AB - Objective: The aim of this study was to evaluate the prognostic value of pre-treatment plasma hemostatic parameters in patients with advanced pancreatic cancer. Methods: A total of 320 patients diagnosed with advanced pancreatic cancer between January 1, 2011 to December 31, 2015 were enrolled in this retrospective study. The prognostic significance of hemostatic parameters such as prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FBG), platelet count (PLT), mean platelet volume (MPV), plateletcrit (PCT), and platelet distribution width (PDW) was determined by univariate and multivariate Cox hazard models. Then, Kaplan-Meier methods and log-rank tests were performed to compare the survival of patients in different risk groups. Result: Univariate and multivariate analyses showed that prolonged PT, high FBG, and high MPV were independent prognostic factors for poor overall survival (PT > 11.3 s, HR = 1.46, 95%CI = 1.10–1.94, p = 0.009; FBG>2.5 g/L, HR = 1.41, 95%CI = 1.08–1.84, p = 0.011; MPV>12.2 fL, HR = 1.52, 95%CI = 1.13–2.04, p = 0.005). Moreover, all the patients were stratified into three groups by a scoring system based on these three hemostatic markers. The median survival time of the three groups was 8.8 months, 6.3 months and 4.3 months (P < 0.001). Conclusion: PT, FBG and MPV were independent prognostic factors in advanced pancreatic cancer. A novel scoring system based on these hemostatic parameters could be used to predict the survival of patients with advanced pancreatic cancer.

KW - Fibrinogen

KW - Mean platelet volume

KW - Pancreatic cancer

KW - Prognosis

KW - Prothrombin time

UR - http://www.scopus.com/inward/record.url?scp=85059692993&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85059692993&partnerID=8YFLogxK

U2 - 10.1016/j.pan.2018.12.010

DO - 10.1016/j.pan.2018.12.010

M3 - Article

VL - 19

SP - 346

EP - 351

JO - Pancreatology

JF - Pancreatology

SN - 1424-3903

IS - 2

ER -