A panel of restriction fragment length polymorphisms for chromosomal band 11p13

Vicki Huff, Duane A. Compton, Louise C. Strong, Grady F. Saunders

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A panel of seven chromosome 11p13 restriction fragment length polymorphisms (RFLPs) detected by five DNA probes is described. Two alleles were identified for each polymorphism, and Mendelian segregation of alleles was observed. Allele frequencies range from 0.13/0.87 to 0.44/0.56. This panel of 11p13 RFLPs will be useful for linkage studies investigating the role of 11p13 genes in Wilms' tumor, aniridia, and genitourinary anomalies. Additionally, these RFLPs will be important tools for studying tumor-specific 11p13 alterations in Wilms' tumor and other cancers.

Original languageEnglish (US)
Pages (from-to)253-257
Number of pages5
JournalHuman genetics
Volume84
Issue number3
DOIs
StatePublished - Feb 1 1990

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Restriction Fragment Length Polymorphisms
Alleles
Wilms' Tumor Genes
Aniridia
Wilms Tumor
DNA Probes
Gene Frequency
Neoplasms
Chromosomes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

A panel of restriction fragment length polymorphisms for chromosomal band 11p13. / Huff, Vicki; Compton, Duane A.; Strong, Louise C.; Saunders, Grady F.

In: Human genetics, Vol. 84, No. 3, 01.02.1990, p. 253-257.

Research output: Contribution to journalArticle

Huff, Vicki ; Compton, Duane A. ; Strong, Louise C. ; Saunders, Grady F. / A panel of restriction fragment length polymorphisms for chromosomal band 11p13. In: Human genetics. 1990 ; Vol. 84, No. 3. pp. 253-257.
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