A Phase II Feasibility Study of Weekly Paclitaxel in Heavily Pretreated Advanced Gastric Cancer Patients with Poor Performance Status

Chong Kun Im, Sun Young Rha, Hei Cheul Jeung, Jaeheon Jeong, Soo Hyeon Lee, Sung Hoon Noh, JaeKyung Roh, Hyun Cheol Chung

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    Abstract

    Purpose: We investigated the efficacy and safety of weekly paclitaxel monotherapy in previously treated patients with advanced gastric cancer (AGC) and poor performance status (PS) according to the Eastern Cooperative Oncology Group (ECOG). Patients and Methods: Patients with evaluable disease who failed at least one previous chemotherapy and had a PS of 2-3, received paclitaxel 70 mg/m2 on days 1, 8 and 15 every 4 weeks. Results: The median overall survival (OS) was 5.5 months (95% confidence interval, CI, 3.3-7.8) and progression-free survival was 2.1 months (95% CI, 1.2-3.0). The overall response rate was 3.8% and the disease control rate was 25.0%. Treatment-related toxicities were tolerable. OS was 7.1 (95% CI, 5.4-9.5) and 3.7 months (95% CI, 2.1-5.3) for patients with PS-ECOG 2 and 3, respectively (p < 0.001). When evaluated according to the previous treatment, OS was 5.1 (95% CI, 3.3-7.0) and 6.5 months (95% CI, 3.8-9.3) for patients receiving two and three or more lines of treatment, respectively (p = 0.815). With multivariate analysis, PS was a significant factor for OS. Conclusion: Survival in patients treated with weekly paclitaxel monotherapy was comparable to other second- or third-line chemotherapies for AGC, with acceptable toxicities in previously treated patients with poor PS.

    Original languageEnglish (US)
    Pages (from-to)349-357
    Number of pages9
    JournalOncology
    Volume77
    Issue number6
    DOIs
    StatePublished - Feb 1 2010

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    Keywords

    • Advanced gastric cancer
    • Paclitaxel monotherapy
    • Poor performance status
    • Weekly paclitaxel

    ASJC Scopus subject areas

    • Oncology
    • Cancer Research

    Cite this

    Im, C. K., Rha, S. Y., Jeung, H. C., Jeong, J., Lee, S. H., Noh, S. H., Roh, J., & Chung, H. C. (2010). A Phase II Feasibility Study of Weekly Paclitaxel in Heavily Pretreated Advanced Gastric Cancer Patients with Poor Performance Status. Oncology, 77(6), 349-357. https://doi.org/10.1159/000265941