Abstract
A double isotope methodology was used to assses the effect of methylxanthine administration on membrane protein synthesis in developing rat brain. Rat pups were given either aminophylline, theophylline, or caffeine in a dosage of 40 mg/kg or 80 mg/kg daily from the second postnatal day through 20 days of age. Results show depressed myelin protein synthesis at 21-24 days by theophylline (80 mg/kg) and caffeine (40 and 80 mg/kg). Synthesis was essentially normal at 27-28 days of age, indicating a possible delay in development followed by a 'catch-up' phenomenon.
Original language | English (US) |
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Pages (from-to) | 476-480 |
Number of pages | 5 |
Journal | Brain Research |
Volume | 213 |
Issue number | 2 |
DOIs | |
State | Published - Jun 1 1981 |
Keywords
- aminophylline
- caffeine
- methylxanthine
- myelin synthesis
- theophylline
ASJC Scopus subject areas
- General Neuroscience
- Molecular Biology
- Clinical Neurology
- Developmental Biology