A preoperative nutritional index for predicting cancer-specific and overall survival in Chinese patients with laryngeal cancer: A retrospective study

Yan Fu, Shu Wei Chen, Shi Qi Chen, Dian Ou-Yang, Wei Wei Liu, Ming Song, An Kui Yang, Quan Zhang

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Abstract

Pinato prognostic nutritional index (PNI) adequately predicts long-term outcomes of various malignancies. However, its value in predicting outcomes in laryngeal squamous cell carcinoma (LSCC) is unknown. All patients newly diagnosed with LSCC presenting to the Department of Head and Neck Oncology at Sun Yat-sen University Cancer Center between January 1, 1990 and July 31, 2010 were eligible. The PNI was calculated as serum albumin (g/L)+5× total lymphocyte count/L. The Cutoff Finder software program was used to classify the patients into 3 groups for which the PNI score was at least 70% sensitive, at least 70% specific, or equivocal. Cancer-specific survival was estimated using the Kaplan-Meier method, and predictors were assessed with Cox regression analysis. Median time between surgery and PNI administration for the 975 eligible patients was 83 months. Index score groups were significantly associatedwith age, T stage, TNMstage, and type of surgery. Five-year CSS and OS were 57.3% and 56.6% in patients with PNI scores below 48.65 (low-probability of survival), 72.8% and 71.3% with scores between 48.65 and 56.93 (moderate-probability of survival), and 77.6% and 75.3% with scores above 56.93 (high-probability of survival); 10-year CSS and OS were 44.2% and 42.7%, 61.6% and 55.6%, 68.3% and 63.5%, respectively. The PNI score groups significantly predicted CSS and OS (P<0.001). The PNI is an inexpensive and readily available score that predicted survival in patients with LSCC after curative laryngectomy.

Original languageEnglish (US)
Article numbere2962
JournalMedicine (United States)
Volume95
Issue number11
DOIs
StatePublished - Jan 1 2016

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Nutrition Assessment
Laryngeal Neoplasms
Retrospective Studies
Survival
Neoplasms
Squamous Cell Carcinoma
Laryngectomy
Lymphocyte Count
Solar System
Serum Albumin
Neck
Software
Head
Regression Analysis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A preoperative nutritional index for predicting cancer-specific and overall survival in Chinese patients with laryngeal cancer : A retrospective study. / Fu, Yan; Chen, Shu Wei; Chen, Shi Qi; Ou-Yang, Dian; Liu, Wei Wei; Song, Ming; Yang, An Kui; Zhang, Quan.

In: Medicine (United States), Vol. 95, No. 11, e2962, 01.01.2016.

Research output: Contribution to journalArticle

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abstract = "Pinato prognostic nutritional index (PNI) adequately predicts long-term outcomes of various malignancies. However, its value in predicting outcomes in laryngeal squamous cell carcinoma (LSCC) is unknown. All patients newly diagnosed with LSCC presenting to the Department of Head and Neck Oncology at Sun Yat-sen University Cancer Center between January 1, 1990 and July 31, 2010 were eligible. The PNI was calculated as serum albumin (g/L)+5× total lymphocyte count/L. The Cutoff Finder software program was used to classify the patients into 3 groups for which the PNI score was at least 70{\%} sensitive, at least 70{\%} specific, or equivocal. Cancer-specific survival was estimated using the Kaplan-Meier method, and predictors were assessed with Cox regression analysis. Median time between surgery and PNI administration for the 975 eligible patients was 83 months. Index score groups were significantly associatedwith age, T stage, TNMstage, and type of surgery. Five-year CSS and OS were 57.3{\%} and 56.6{\%} in patients with PNI scores below 48.65 (low-probability of survival), 72.8{\%} and 71.3{\%} with scores between 48.65 and 56.93 (moderate-probability of survival), and 77.6{\%} and 75.3{\%} with scores above 56.93 (high-probability of survival); 10-year CSS and OS were 44.2{\%} and 42.7{\%}, 61.6{\%} and 55.6{\%}, 68.3{\%} and 63.5{\%}, respectively. The PNI score groups significantly predicted CSS and OS (P<0.001). The PNI is an inexpensive and readily available score that predicted survival in patients with LSCC after curative laryngectomy.",
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