A Promising CPS1 Inhibitor Keeping Ammonia from Fueling Cancer

Research output: Contribution to journalComment/debatepeer-review

7 Scopus citations

Abstract

Carbamoyl phosphate synthetase 1 (CPS1) drives ammonia conversion to carbamoyl phosphate, and its overexpression supports pyrimidine synthesis and tumor growth, highlighting the potential of CPS1 inhibition as a therapeutic target. In this issue of Cell Chemical Biology, Yao et al. (2020) introduce H3B-120 as a promising novel inhibitor of CPS1.

Original languageEnglish (US)
Pages (from-to)253-254
Number of pages2
JournalCell Chemical Biology
Volume27
Issue number3
DOIs
StatePublished - Mar 19 2020

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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