TY - JOUR
T1 - A Promising CPS1 Inhibitor Keeping Ammonia from Fueling Cancer
AU - Taguchi, Ayumu
AU - Fahrmann, Johannes F.
AU - Hanash, Samir M.
N1 - Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2020/3/19
Y1 - 2020/3/19
N2 - Carbamoyl phosphate synthetase 1 (CPS1) drives ammonia conversion to carbamoyl phosphate, and its overexpression supports pyrimidine synthesis and tumor growth, highlighting the potential of CPS1 inhibition as a therapeutic target. In this issue of Cell Chemical Biology, Yao et al. (2020) introduce H3B-120 as a promising novel inhibitor of CPS1.
AB - Carbamoyl phosphate synthetase 1 (CPS1) drives ammonia conversion to carbamoyl phosphate, and its overexpression supports pyrimidine synthesis and tumor growth, highlighting the potential of CPS1 inhibition as a therapeutic target. In this issue of Cell Chemical Biology, Yao et al. (2020) introduce H3B-120 as a promising novel inhibitor of CPS1.
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U2 - 10.1016/j.chembiol.2020.03.002
DO - 10.1016/j.chembiol.2020.03.002
M3 - Comment/debate
C2 - 32200911
AN - SCOPUS:85081295830
SN - 2451-9456
VL - 27
SP - 253
EP - 254
JO - Cell Chemical Biology
JF - Cell Chemical Biology
IS - 3
ER -