A prospective evaluation of health-related quality of life after skull base re-irradiation

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Purpose: To report cancer control outcomes and health-related quality of life (HRQoL) outcomes after highly conformal skull-based re-irradiation (re-RT). Methods: Patients planned for curative intent re-RT to a recurrent or new skull base tumor were enrolled. HRQoL were assessed using the MD Anderson Symptom Inventory Brain Tumor (MDASI-BT) and the anterior skull base surgery quality of life (ASBQ) questionnaires. Results: Thirty-nine patients were treated with stereotactic body RT or intensity modulated RT. Median follow-up was 14 months. Progression free survival was 71% at 1-year. There was mild clinically significant worsening of fatigue, lack of appetite and drowsiness (MDASI-BT), and physical function (ASBQ) at the end of RT, followed by recovery to baseline on subsequent follow-ups. Subjective emotions were clinically improved at 12 months, with patients reporting feeling less tense/nervous. Conclusion: Conformal skull base re-RT is associated with mild immediate deterioration in physical function followed by rapid and sustained recovery.

Original languageEnglish (US)
Pages (from-to)485-497
Number of pages13
JournalHead and Neck
Issue number3
StatePublished - Mar 1 2020


  • health-related quality of life
  • intensity modulation
  • patient-reported outcomes
  • quality of life
  • re-irradiation
  • skull base tumor
  • stereotactic body radiotherapy

ASJC Scopus subject areas

  • Otorhinolaryngology

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