A prospective evaluation of health-related quality of life after skull base re-irradiation

Houda Bahig; Sweet P. Ng; Courtney Pollard; Theresa P. Nguyen; Gary B. Gunn; David I. Rosenthal; Clifton D. Fuller; Steven J. Frank; Adam S. Garden; Jay P. Reddy; William H. Morrison; Renata Ferrarotto; Ehab Y. Hanna; Franco DeMonte; Shirley Y. Su; Jack Phan

doi:10.1002/hed.26037

A prospective evaluation of health-related quality of life after skull base re-irradiation

Houda Bahig, Sweet P. Ng, Courtney Pollard, Theresa P. Nguyen, Gary B. Gunn, David I. Rosenthal, Clifton D. Fuller, Steven J. Frank, Adam S. Garden, Jay P. Reddy, William H. Morrison, Renata Ferrarotto, Ehab Y. Hanna, Franco DeMonte, Shirley Y. Su, Jack Phan

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Purpose: To report cancer control outcomes and health-related quality of life (HRQoL) outcomes after highly conformal skull-based re-irradiation (re-RT). Methods: Patients planned for curative intent re-RT to a recurrent or new skull base tumor were enrolled. HRQoL were assessed using the MD Anderson Symptom Inventory Brain Tumor (MDASI-BT) and the anterior skull base surgery quality of life (ASBQ) questionnaires. Results: Thirty-nine patients were treated with stereotactic body RT or intensity modulated RT. Median follow-up was 14 months. Progression free survival was 71% at 1-year. There was mild clinically significant worsening of fatigue, lack of appetite and drowsiness (MDASI-BT), and physical function (ASBQ) at the end of RT, followed by recovery to baseline on subsequent follow-ups. Subjective emotions were clinically improved at 12 months, with patients reporting feeling less tense/nervous. Conclusion: Conformal skull base re-RT is associated with mild immediate deterioration in physical function followed by rapid and sustained recovery.

Original language	English (US)
Pages (from-to)	485-497
Number of pages	13
Journal	Head and Neck
Volume	42
Issue number	3
DOIs	https://doi.org/10.1002/hed.26037
State	Published - Mar 1 2020

Keywords

health-related quality of life
intensity modulation
patient-reported outcomes
quality of life
re-irradiation
skull base tumor
stereotactic body radiotherapy

ASJC Scopus subject areas

Otorhinolaryngology

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10.1002/hed.26037

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Bahig, H., Ng, S. P., Pollard, C., Nguyen, T. P., Gunn, G. B., Rosenthal, D. I., Fuller, C. D., Frank, S. J., Garden, A. S., Reddy, J. P., Morrison, W. H., Ferrarotto, R., Hanna, E. Y., DeMonte, F., Su, S. Y., & Phan, J. (2020). A prospective evaluation of health-related quality of life after skull base re-irradiation. Head and Neck, 42(3), 485-497. https://doi.org/10.1002/hed.26037

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title = "A prospective evaluation of health-related quality of life after skull base re-irradiation",

abstract = "Purpose: To report cancer control outcomes and health-related quality of life (HRQoL) outcomes after highly conformal skull-based re-irradiation (re-RT). Methods: Patients planned for curative intent re-RT to a recurrent or new skull base tumor were enrolled. HRQoL were assessed using the MD Anderson Symptom Inventory Brain Tumor (MDASI-BT) and the anterior skull base surgery quality of life (ASBQ) questionnaires. Results: Thirty-nine patients were treated with stereotactic body RT or intensity modulated RT. Median follow-up was 14 months. Progression free survival was 71% at 1-year. There was mild clinically significant worsening of fatigue, lack of appetite and drowsiness (MDASI-BT), and physical function (ASBQ) at the end of RT, followed by recovery to baseline on subsequent follow-ups. Subjective emotions were clinically improved at 12 months, with patients reporting feeling less tense/nervous. Conclusion: Conformal skull base re-RT is associated with mild immediate deterioration in physical function followed by rapid and sustained recovery.",

keywords = "health-related quality of life, intensity modulation, patient-reported outcomes, quality of life, re-irradiation, skull base tumor, stereotactic body radiotherapy",

author = "Houda Bahig and Ng, {Sweet P.} and Courtney Pollard and Nguyen, {Theresa P.} and Gunn, {Gary B.} and Rosenthal, {David I.} and Fuller, {Clifton D.} and Frank, {Steven J.} and Garden, {Adam S.} and Reddy, {Jay P.} and Morrison, {William H.} and Renata Ferrarotto and Hanna, {Ehab Y.} and Franco DeMonte and Su, {Shirley Y.} and Jack Phan",

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doi = "10.1002/hed.26037",

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AU - Bahig, Houda

AU - Ng, Sweet P.

AU - Pollard, Courtney

AU - Nguyen, Theresa P.

AU - Gunn, Gary B.

AU - Rosenthal, David I.

AU - Fuller, Clifton D.

AU - Frank, Steven J.

AU - Garden, Adam S.

AU - Reddy, Jay P.

AU - Morrison, William H.

AU - Ferrarotto, Renata

AU - Hanna, Ehab Y.

AU - DeMonte, Franco

AU - Su, Shirley Y.

AU - Phan, Jack

PY - 2020/3/1

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N2 - Purpose: To report cancer control outcomes and health-related quality of life (HRQoL) outcomes after highly conformal skull-based re-irradiation (re-RT). Methods: Patients planned for curative intent re-RT to a recurrent or new skull base tumor were enrolled. HRQoL were assessed using the MD Anderson Symptom Inventory Brain Tumor (MDASI-BT) and the anterior skull base surgery quality of life (ASBQ) questionnaires. Results: Thirty-nine patients were treated with stereotactic body RT or intensity modulated RT. Median follow-up was 14 months. Progression free survival was 71% at 1-year. There was mild clinically significant worsening of fatigue, lack of appetite and drowsiness (MDASI-BT), and physical function (ASBQ) at the end of RT, followed by recovery to baseline on subsequent follow-ups. Subjective emotions were clinically improved at 12 months, with patients reporting feeling less tense/nervous. Conclusion: Conformal skull base re-RT is associated with mild immediate deterioration in physical function followed by rapid and sustained recovery.

AB - Purpose: To report cancer control outcomes and health-related quality of life (HRQoL) outcomes after highly conformal skull-based re-irradiation (re-RT). Methods: Patients planned for curative intent re-RT to a recurrent or new skull base tumor were enrolled. HRQoL were assessed using the MD Anderson Symptom Inventory Brain Tumor (MDASI-BT) and the anterior skull base surgery quality of life (ASBQ) questionnaires. Results: Thirty-nine patients were treated with stereotactic body RT or intensity modulated RT. Median follow-up was 14 months. Progression free survival was 71% at 1-year. There was mild clinically significant worsening of fatigue, lack of appetite and drowsiness (MDASI-BT), and physical function (ASBQ) at the end of RT, followed by recovery to baseline on subsequent follow-ups. Subjective emotions were clinically improved at 12 months, with patients reporting feeling less tense/nervous. Conclusion: Conformal skull base re-RT is associated with mild immediate deterioration in physical function followed by rapid and sustained recovery.

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KW - intensity modulation

KW - patient-reported outcomes

KW - quality of life

KW - re-irradiation

KW - skull base tumor

KW - stereotactic body radiotherapy

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A prospective evaluation of health-related quality of life after skull base re-irradiation

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Keywords

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