@article{19633e632fa04169968080478cf9cf64,
title = "A prospective feasibility study evaluating the 5x-multiplier to standardize discharge prescriptions in cancer surgery patients",
abstract = "Background: We designed a prospective feasibility study to assess the 5x-multiplier (5x) calculation (eg, 3 pills in last 24 hours × 5 = 15) to standardize discharge opioid prescriptions compared to usual care. Methods: Faculty-based surgical teams volunteered for either 5x or usual care arms. Patients undergoing inpatient (≥ 48 hours) surgery and discharged by surgical teams were included. The primary end point was discharge oral morphine equivalents. Secondary end points were opioid-free discharges and 30-day refill rates. Results: Median last 24-hour oral morphine equivalents was similar between arms (7.5 mg 5x vs 10 mg usual care, P = .830). Median discharge oral morphine equivalents were less in the 5x arm (50 mg 5x vs 75 mg usual care, P < .001). Opioid-free discharges included 33.5% 5x vs 18.0% usual care arm patients (P < .001). Thirty-day refill rates were similar (15.3% 5x vs 16.5% usual care, P = .742). Conclusion: The 5x-multiplier was associated with reduced opioid prescriptions without increased refills and can be feasibly implemented across a diverse surgical practice.",
author = "{for the PROMOTE Consortium} and DiPeri, {Timothy P.} and Newhook, {Timothy E.} and Day, {Ryan W.} and Chiang, {Yi Ju} and Dewhurst, {Whitney L.} and Arvide, {Elsa M.} and Bruno, {Morgan L.} and Scally, {Christopher P.} and Roland, {Christina L.} and Katz, {Matthew H.G.} and Vauthey, {Jean Nicolas} and Chang, {George J.} and Badgwell, {Brian D.} and Perrier, {Nancy D.} and Grubbs, {Elizabeth G.} and Lee, {Jeffrey E.} and Tzeng, {Ching Wei D.} and Bednarski, {Brian K.} and Chen, {Iris B.} and Comeaux, {Ryan J.} and Cox, {Dana M.} and Feig, {Barry W.} and Fisher, {Sarah B.} and Fournier, {Keith F.} and Ghebremichael, {Semhar J.} and Gibson, {Heather M.} and Gourmelon, {Nicole C.} and Graham, {Paul H.} and Shannon Hancher and Hunt, {Kelly K.} and Naruhiko Ikoma and {Ivey MPAS}, {Shanae L.} and Keung, {Emily Z.} and Ledet, {Celia R.} and Limmer, {Angela R.} and Mansfield, {Paul F.} and Mayon, {Lauren K.} and Messick, {Craig A.} and Popat, {Keyuri U.} and {Rajkot MPAS}, {Nikita F.} and Rodriguez-Bigas, {Miguel A.} and Santos, {David A.} and Skibber, {John M.} and Speer, {B. Bryce} and Jose Soliz and Tillman, {Matthew M.} and Torres, {Keila E.} and {van Meter}, Antoinette and Williams, {Uduak Ursula} and You, {Y. Nancy}",
note = "Publisher Copyright: {\textcopyright} 2022 The Authors",
year = "2022",
month = jul,
doi = "10.1016/j.sopen.2022.04.004",
language = "English (US)",
volume = "9",
pages = "51--57",
journal = "Surgery Open Science",
issn = "2589-8450",
publisher = "Elsevier BV",
}