TY - JOUR
T1 - A Randomized Controlled Trial of Brief Mindfulness Meditation for Women Undergoing Stereotactic Breast Biopsy
AU - Ratcliff, Chelsea G.
AU - Prinsloo, Sarah
AU - Chaoul, Alejandro
AU - Zepeda, Stephanie G.
AU - Cannon, Rex
AU - Spelman, Amy
AU - Yang, Wei T.
AU - Cohen, Lorenzo
N1 - Funding Information:
This work was supported by a National Cancer Institute cancer prevention fellowship for Chelsea G. Ratcliff (grant R25T CA057730; Shine Chang, principal investigator) and National Cancer Institute Cancer Center Support (grant A016672).
Funding Information:
This work was supported by a National Cancer Institute cancer prevention fellowship for Chelsea G. Ratcliff (grant R25T CA057730 ; Shine Chang, principal investigator) and National Cancer Institute Cancer Center Support (grant A016672 ).
Publisher Copyright:
© 2018
PY - 2019/5
Y1 - 2019/5
N2 - Purpose: Stereotactic breast biopsy (SBB) is a common, anxiety-producing procedure. Nonpharmacologic methods to manage acute anxiety are needed. Methods: In this single-blind trial, women were recruited before SBB and randomized in a 2:2:1 ratio to a single session of guided mindfulness-based meditation (GM; n = 30), focused breathing (FB; n = 30), or standard care (SC; n = 16). Anxiety and pain were assessed at baseline after a 10-min prebiopsy group-specific activity (GM, FB, or SC), every 4 min during SBB, and after biopsy. Electroencephalographic activity in the medial prefrontal cortex, insula, anterior cingulate cortex, and precuneus was collected throughout the study. Results: Women in the GM group reported a steeper reduction in anxiety than women in the FB and SC groups (P <.001 for all, Cohen's d > 0.4 for all). There were no group differences in pain ratings during the biopsy. Women in the GM group experienced increased beta activity during biopsy in the insula (P =.006, Cohen's d = 1.4) and anterior cingulate cortex (P =.019, Cohen's d = 1.0) compared with women in the SC group, and there was a trend toward the same effect compared with women in the FB group (P <.10 for both). Women in the GM and FB groups experienced a nonsignificant decrease in delta activity in the precuneus during biopsy compared with those in the SC group (P <.40 for both, Cohen's d > 0.6 for both), which was associated with a steeper reduction in anxiety during the biopsy (r = 0.51, P <.01). Conclusions: Brief, guided meditation may provide effective anxiety relief during an acute medical procedure and affect neuronal activity in regions associated with attention, self-awareness, and emotion regulation.
AB - Purpose: Stereotactic breast biopsy (SBB) is a common, anxiety-producing procedure. Nonpharmacologic methods to manage acute anxiety are needed. Methods: In this single-blind trial, women were recruited before SBB and randomized in a 2:2:1 ratio to a single session of guided mindfulness-based meditation (GM; n = 30), focused breathing (FB; n = 30), or standard care (SC; n = 16). Anxiety and pain were assessed at baseline after a 10-min prebiopsy group-specific activity (GM, FB, or SC), every 4 min during SBB, and after biopsy. Electroencephalographic activity in the medial prefrontal cortex, insula, anterior cingulate cortex, and precuneus was collected throughout the study. Results: Women in the GM group reported a steeper reduction in anxiety than women in the FB and SC groups (P <.001 for all, Cohen's d > 0.4 for all). There were no group differences in pain ratings during the biopsy. Women in the GM group experienced increased beta activity during biopsy in the insula (P =.006, Cohen's d = 1.4) and anterior cingulate cortex (P =.019, Cohen's d = 1.0) compared with women in the SC group, and there was a trend toward the same effect compared with women in the FB group (P <.10 for both). Women in the GM and FB groups experienced a nonsignificant decrease in delta activity in the precuneus during biopsy compared with those in the SC group (P <.40 for both, Cohen's d > 0.6 for both), which was associated with a steeper reduction in anxiety during the biopsy (r = 0.51, P <.01). Conclusions: Brief, guided meditation may provide effective anxiety relief during an acute medical procedure and affect neuronal activity in regions associated with attention, self-awareness, and emotion regulation.
KW - EEG
KW - Meditation
KW - anxiety
KW - breast biopsy
KW - breast cancer
KW - pain
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U2 - 10.1016/j.jacr.2018.09.009
DO - 10.1016/j.jacr.2018.09.009
M3 - Article
C2 - 30322793
AN - SCOPUS:85064491384
SN - 1546-1440
VL - 16
SP - 691
EP - 699
JO - Journal of the American College of Radiology
JF - Journal of the American College of Radiology
IS - 5
ER -