A randomized parallel-group dietary study for stages II-IV ovarian cancer survivors

Raheem J. Paxton, Celia Garcia-Prieto, Maria Berglund, Mike Hernandez, Richard A. Hajek, Beverly Handy, Jubilee Brown, Lovell A. Jones

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objective: Few studies have examined the dietary habits of ovarian cancer survivors. Therefore, we conducted a study to assess the feasibility and impact of two dietary interventions for ovarian cancer survivors. Methods: In this randomized, parallel-group study, 51 women (mean age, 53 years) diagnosed with stages II-IV ovarian cancer were recruited and randomly assigned to a low fat, high fiber (LFHF) diet or a modified National Cancer Institute diet supplemented with a soy-based beverage and encapsulated fruit and vegetable juice concentrates (FVJCs). Changes in clinical measures, serum carotenoid and tocopherol levels, dietary intake, anthropometry, and health-related quality of life (HRQOL) were assessed with paired t-tests. Results: The recruitment rate was 25%, and the retention rate was 75% at 6 months. At baseline, 28% and 45% of women met guidelines for intake of fiber and of fruits and vegetables, respectively. After 6 months, total serum carotenoid levels and α- and β-carotene concentrations were significantly increased in both groups (P < 0.01); however, β-carotene concentrations were increased more in the FVJC group. Serum β-cryptoxanthin levels, fiber intake (+ 5.2 g/day), and daily servings of juice (+ 0.9 servings/day) and vegetables (+ 1.3 servings/day) were all significantly increased in the LFHF group (all P < 0.05). Serum levels of albumin, lutein and zeaxanthin, retinol, and retinyl palmitate were significantly increased in the FVJC group (all P < 0.05). No changes in cancer antigen-125, anthropometry, or HRQOL were observed. Conclusion: Overall, this study supports the feasibility of designing dietary interventions for stages II-IV ovarian cancer survivors and provides preliminary evidence that a low fat high fiber diet and a diet supplemented with encapsulated FVJC may increase phytonutrients in ovarian cancer survivors.

Original languageEnglish (US)
Pages (from-to)410-416
Number of pages7
JournalGynecologic oncology
Volume124
Issue number3
DOIs
StatePublished - Mar 1 2012

Fingerprint

Ovarian Neoplasms
Survivors
Carotenoids
Anthropometry
High Fat Diet
Vegetables
Serum
Soy Milk
Quality of Life
Diet
Lutein
Tocopherols
National Cancer Institute (U.S.)
Phytochemicals
Feasibility Studies
Feeding Behavior
Serum Albumin
Fruit
Fats
Guidelines

Keywords

  • Cancer survivors
  • Carotenoids
  • Comparative effectiveness
  • Diet
  • Ovarian cancer
  • Randomized study

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

Cite this

Paxton, R. J., Garcia-Prieto, C., Berglund, M., Hernandez, M., Hajek, R. A., Handy, B., ... Jones, L. A. (2012). A randomized parallel-group dietary study for stages II-IV ovarian cancer survivors. Gynecologic oncology, 124(3), 410-416. https://doi.org/10.1016/j.ygyno.2011.11.031

A randomized parallel-group dietary study for stages II-IV ovarian cancer survivors. / Paxton, Raheem J.; Garcia-Prieto, Celia; Berglund, Maria; Hernandez, Mike; Hajek, Richard A.; Handy, Beverly; Brown, Jubilee; Jones, Lovell A.

In: Gynecologic oncology, Vol. 124, No. 3, 01.03.2012, p. 410-416.

Research output: Contribution to journalArticle

Paxton, RJ, Garcia-Prieto, C, Berglund, M, Hernandez, M, Hajek, RA, Handy, B, Brown, J & Jones, LA 2012, 'A randomized parallel-group dietary study for stages II-IV ovarian cancer survivors', Gynecologic oncology, vol. 124, no. 3, pp. 410-416. https://doi.org/10.1016/j.ygyno.2011.11.031
Paxton, Raheem J. ; Garcia-Prieto, Celia ; Berglund, Maria ; Hernandez, Mike ; Hajek, Richard A. ; Handy, Beverly ; Brown, Jubilee ; Jones, Lovell A. / A randomized parallel-group dietary study for stages II-IV ovarian cancer survivors. In: Gynecologic oncology. 2012 ; Vol. 124, No. 3. pp. 410-416.
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