A review of particle therapy for skull base tumors: Modern considerations and future directions

Eugen B. Hug; MacIej Pelak; Steven J. Frank; Piero Fossati

doi:10.14338/IJPT-20-00083

A review of particle therapy for skull base tumors: Modern considerations and future directions

Eugen B. Hug, MacIej Pelak, Steven J. Frank, Piero Fossati

Radiation Oncology

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

Skull base tumors constitute one of the established indications for particle therapy, specifically proton therapy. However, a number of prognostic factors, practical clinical management issues, and the emerging role of carbon ion therapy remain subjects of active clinical investigation. This review summarizes these topics, assesses the present status, and reflects on future research directions focusing on the management of chordomas, one of the most aggressive skull base tumors. In addition, the role of particle therapy for benign tumors of the skull base, including pituitary adenoma and acoustic neuroma, is reviewed.

Original language	English (US)
Pages (from-to)	168-178
Number of pages	11
Journal	International Journal of Particle Therapy
Volume	8
Issue number	1
DOIs	https://doi.org/10.14338/IJPT-20-00083
State	Published - Jun 1 2021

Keywords

Carbon ion therapy
Chordoma
Particle therapy
Proton beam therapy
Skull base tumors

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics
Radiology Nuclear Medicine and imaging

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abstract = "Skull base tumors constitute one of the established indications for particle therapy, specifically proton therapy. However, a number of prognostic factors, practical clinical management issues, and the emerging role of carbon ion therapy remain subjects of active clinical investigation. This review summarizes these topics, assesses the present status, and reflects on future research directions focusing on the management of chordomas, one of the most aggressive skull base tumors. In addition, the role of particle therapy for benign tumors of the skull base, including pituitary adenoma and acoustic neuroma, is reviewed.",

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AU - Fossati, Piero

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N2 - Skull base tumors constitute one of the established indications for particle therapy, specifically proton therapy. However, a number of prognostic factors, practical clinical management issues, and the emerging role of carbon ion therapy remain subjects of active clinical investigation. This review summarizes these topics, assesses the present status, and reflects on future research directions focusing on the management of chordomas, one of the most aggressive skull base tumors. In addition, the role of particle therapy for benign tumors of the skull base, including pituitary adenoma and acoustic neuroma, is reviewed.

AB - Skull base tumors constitute one of the established indications for particle therapy, specifically proton therapy. However, a number of prognostic factors, practical clinical management issues, and the emerging role of carbon ion therapy remain subjects of active clinical investigation. This review summarizes these topics, assesses the present status, and reflects on future research directions focusing on the management of chordomas, one of the most aggressive skull base tumors. In addition, the role of particle therapy for benign tumors of the skull base, including pituitary adenoma and acoustic neuroma, is reviewed.

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KW - Particle therapy

KW - Proton beam therapy

KW - Skull base tumors

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A review of particle therapy for skull base tumors: Modern considerations and future directions

Abstract

Keywords

ASJC Scopus subject areas

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