A review of physical activity in pancreatic ductal adenocarcinoma: Epidemiology, intervention, animal models, and clinical trials

Hsiang Yin Hsueh, Valentina Pita-Grisanti, Kristyn Gumpper-Fedus, Ali Lahooti, Myrriah Chavez-Tomar, Keri Schadler, Zobeida Cruz-Monserrate

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest types of cancer, and the increasing incidence of PDAC may be related to the prevalence of obesity. Physical activity (PA), a method known to mitigate obesity by increasing total energy expenditure, also modifies multiple cellular pathways associated with cancer hallmarks. Epidemiologic evidence has shown that PA can lower the risk of developing a variety of cancers, reduce some of the detrimental side effects of treatments, and improve patient's quality of life during cancer treatment. However, little is known about the pathways underlying the correlations observed between PA interventions and PDAC. Moreover, there is no standard dose of PA intervention that is ideal for PDAC prevention or as an adjuvant of cancer treatments. In this review, we summarize relevant literature showing how PDAC patients can benefit from PA, the potential of PA as an adjuvant treatment for PDAC, the studies using preclinical models of PDAC to study PA, and the clinical trials to date assessing the effects of PA in PDAC.

Original languageEnglish (US)
Pages (from-to)98-111
Number of pages14
JournalPancreatology
Volume22
Issue number1
DOIs
StatePublished - Jan 2022

Keywords

  • Exercise
  • Pancreatic cancer
  • Pancreatic ductal adenocarcinoma
  • Physical activity
  • Translational research

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Gastroenterology

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