TY - JOUR
T1 - A Summary of the Inaugural WHO Classification of Pediatric Tumors
T2 - Transitioning from the Optical into the Molecular Era
AU - Pfister, Stefan M.
AU - Reyes-Múgica, Miguel
AU - Chan, John K.C.
AU - Hasle, Henrik
AU - Lazar, Alexander J.
AU - Rossi, Sabrina
AU - Ferrari, Andrea
AU - Jarzembowski, Jason A.
AU - Pritchard-Jones, Kathy
AU - Hill, D. Ashley
AU - Jacques, Thomas S.
AU - Wesseling, Pieter
AU - López Terrada, Dolores H.
AU - von Deimling, Andreas
AU - Kratz, Christian P.
AU - Cree, Ian A.
AU - Alaggio, Rita
N1 - Publisher Copyright:
© 2021 The Authors; Published by the American Association for Cancer Research.
PY - 2022/2/1
Y1 - 2022/2/1
N2 - Pediatric tumors are uncommon, yet are the leading cause of cancer-related death in childhood. Tumor types, molecular characteristics, and pathogenesis are unique, often originating from a single genetic driver event. The specific diagnostic challenges of childhood tumors led to the development of the first World Health Organization (WHO) Classification of Pediatric Tumors. The classification is rooted in a multilayered approach, incorporating morphology, IHC, and molecular characteristics. The volume is organized according to organ sites and provides a single, state-of-the-art compendium of pediatric tumor types. A special emphasis was placed on “blastomas,” which variably recapitulate the morphologic maturation of organs from which they originate.
AB - Pediatric tumors are uncommon, yet are the leading cause of cancer-related death in childhood. Tumor types, molecular characteristics, and pathogenesis are unique, often originating from a single genetic driver event. The specific diagnostic challenges of childhood tumors led to the development of the first World Health Organization (WHO) Classification of Pediatric Tumors. The classification is rooted in a multilayered approach, incorporating morphology, IHC, and molecular characteristics. The volume is organized according to organ sites and provides a single, state-of-the-art compendium of pediatric tumor types. A special emphasis was placed on “blastomas,” which variably recapitulate the morphologic maturation of organs from which they originate.
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U2 - 10.1158/2159-8290.CD-21-1094
DO - 10.1158/2159-8290.CD-21-1094
M3 - Review article
C2 - 34921008
AN - SCOPUS:85124440493
SN - 2159-8274
VL - 12
SP - 331
EP - 355
JO - Cancer discovery
JF - Cancer discovery
IS - 2
ER -