A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression

Guermarie Velazquez-Torres; Einav Shoshan; Cristina Ivan; Li Huang; Enrique Fuentes-Mattei; Harrison Paret; Sun Jin Kim; Cristian Rodriguez-Aguayo; Victoria Xie; Denise Brooks; Steven J.M. Jones; A. Gordon Robertson; George Calin; Gabriel Lopez-Berenstein; Anil Sood; Menashe Bar-Eli

doi:10.1038/s41467-018-02851-7

A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression

Guermarie Velazquez-Torres, Einav Shoshan, Cristina Ivan, Li Huang, Enrique Fuentes-Mattei, Harrison Paret, Sun Jin Kim, Cristian Rodriguez-Aguayo, Victoria Xie, Denise Brooks, Steven J.M. Jones, A. Gordon Robertson, George Calin, Gabriel Lopez-Berenstein, Anil Sood, Menashe Bar-Eli

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Abstract

Previously we have reported that metastatic melanoma cell lines and tumor specimens have reduced expression of ADAR1 and consequently are impaired in their ability to perform A-to-I microRNA (miRNA) editing. The effects of A-to-I miRNAs editing on melanoma growth and metastasis are yet to be determined. Here we report that miR-378a-3p is undergoing A-to-I editing only in the non-metastatic but not in metastatic melanoma cells. The function of the edited form is different from its wild-type counterpart. The edited form of miR-378a-3p preferentially binds to the 3′-UTR of the PARVA oncogene and inhibits its expression, thus preventing the progression of melanoma towards the malignant phenotype. Indeed, edited miR-378a-3p but not its WT form inhibits melanoma metastasis in vivo. These results further emphasize the role of RNA editing in melanoma progression.

Original language	English (US)
Article number	461
Journal	Nature communications
Volume	9
Issue number	1
DOIs	https://doi.org/10.1038/s41467-018-02851-7
State	Published - Dec 1 2018

ASJC Scopus subject areas

General Chemistry
General Biochemistry, Genetics and Molecular Biology
General Physics and Astronomy

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10.1038/s41467-018-02851-7

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Velazquez-Torres, G., Shoshan, E., Ivan, C., Huang, L., Fuentes-Mattei, E., Paret, H., Kim, S. J., Rodriguez-Aguayo, C., Xie, V., Brooks, D., Jones, S. J. M., Robertson, A. G., Calin, G., Lopez-Berenstein, G., Sood, A., & Bar-Eli, M. (2018). A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression. Nature communications, 9(1), Article 461. https://doi.org/10.1038/s41467-018-02851-7

Velazquez-Torres, G, Shoshan, E, Ivan, C, Huang, L, Fuentes-Mattei, E, Paret, H, Kim, SJ, Rodriguez-Aguayo, C, Xie, V, Brooks, D, Jones, SJM, Robertson, AG, Calin, G , Lopez-Berenstein, G , Sood, A & Bar-Eli, M 2018, 'A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression', Nature communications, vol. 9, no. 1, 461. https://doi.org/10.1038/s41467-018-02851-7

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title = "A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression",

abstract = "Previously we have reported that metastatic melanoma cell lines and tumor specimens have reduced expression of ADAR1 and consequently are impaired in their ability to perform A-to-I microRNA (miRNA) editing. The effects of A-to-I miRNAs editing on melanoma growth and metastasis are yet to be determined. Here we report that miR-378a-3p is undergoing A-to-I editing only in the non-metastatic but not in metastatic melanoma cells. The function of the edited form is different from its wild-type counterpart. The edited form of miR-378a-3p preferentially binds to the 3′-UTR of the PARVA oncogene and inhibits its expression, thus preventing the progression of melanoma towards the malignant phenotype. Indeed, edited miR-378a-3p but not its WT form inhibits melanoma metastasis in vivo. These results further emphasize the role of RNA editing in melanoma progression.",

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AU - Fuentes-Mattei, Enrique

AU - Paret, Harrison

AU - Kim, Sun Jin

AU - Rodriguez-Aguayo, Cristian

AU - Xie, Victoria

AU - Brooks, Denise

AU - Jones, Steven J.M.

AU - Robertson, A. Gordon

AU - Calin, George

AU - Lopez-Berenstein, Gabriel

AU - Sood, Anil

AU - Bar-Eli, Menashe

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N2 - Previously we have reported that metastatic melanoma cell lines and tumor specimens have reduced expression of ADAR1 and consequently are impaired in their ability to perform A-to-I microRNA (miRNA) editing. The effects of A-to-I miRNAs editing on melanoma growth and metastasis are yet to be determined. Here we report that miR-378a-3p is undergoing A-to-I editing only in the non-metastatic but not in metastatic melanoma cells. The function of the edited form is different from its wild-type counterpart. The edited form of miR-378a-3p preferentially binds to the 3′-UTR of the PARVA oncogene and inhibits its expression, thus preventing the progression of melanoma towards the malignant phenotype. Indeed, edited miR-378a-3p but not its WT form inhibits melanoma metastasis in vivo. These results further emphasize the role of RNA editing in melanoma progression.

AB - Previously we have reported that metastatic melanoma cell lines and tumor specimens have reduced expression of ADAR1 and consequently are impaired in their ability to perform A-to-I microRNA (miRNA) editing. The effects of A-to-I miRNAs editing on melanoma growth and metastasis are yet to be determined. Here we report that miR-378a-3p is undergoing A-to-I editing only in the non-metastatic but not in metastatic melanoma cells. The function of the edited form is different from its wild-type counterpart. The edited form of miR-378a-3p preferentially binds to the 3′-UTR of the PARVA oncogene and inhibits its expression, thus preventing the progression of melanoma towards the malignant phenotype. Indeed, edited miR-378a-3p but not its WT form inhibits melanoma metastasis in vivo. These results further emphasize the role of RNA editing in melanoma progression.

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A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression

Abstract

ASJC Scopus subject areas

MD Anderson CCSG core facilities

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