Ablation of Stromal Cells with a Targeted Proapoptotic Peptide Suppresses Cancer Chemotherapy Resistance and Metastasis

Fei Su; Xiaoping Wang; Troy Pearson; Jangsoon Lee; Savitri Krishnamurthy; Naoto T. Ueno; Mikhail G. Kolonin

doi:10.1016/j.omto.2020.08.012

Ablation of Stromal Cells with a Targeted Proapoptotic Peptide Suppresses Cancer Chemotherapy Resistance and Metastasis

Fei Su, Xiaoping Wang, Troy Pearson, Jangsoon Lee, Savitri Krishnamurthy, Naoto T. Ueno, Mikhail G. Kolonin

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

This study improves our understanding of how tumor stromal cells recruited from fat tissue stimulate carcinoma progression to chemotherapy resistance and metastasis. A combination of chemotherapy and experimental pharmacological adipose stromal cell ablation reduced the metastatic burden in mouse models, hence establishing a new approach to cancer treatment.

Original language	English (US)
Pages (from-to)	579-586
Number of pages	8
Journal	Molecular Therapy Oncolytics
Volume	18
DOIs	https://doi.org/10.1016/j.omto.2020.08.012
State	Published - Sep 25 2020

Keywords

EMT
adipose stromal cell
breast
cancer
cancer fibroblast
chemotherapy
metastasis
obesity
peptide
targeting

ASJC Scopus subject areas

Molecular Medicine
Oncology
Cancer Research
Pharmacology (medical)

MD Anderson CCSG core facilities

Research Animal Support Facility
Small Animal Imaging Facility

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10.1016/j.omto.2020.08.012

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title = "Ablation of Stromal Cells with a Targeted Proapoptotic Peptide Suppresses Cancer Chemotherapy Resistance and Metastasis",

abstract = "This study improves our understanding of how tumor stromal cells recruited from fat tissue stimulate carcinoma progression to chemotherapy resistance and metastasis. A combination of chemotherapy and experimental pharmacological adipose stromal cell ablation reduced the metastatic burden in mouse models, hence establishing a new approach to cancer treatment.",

keywords = "EMT, adipose stromal cell, breast, cancer, cancer fibroblast, chemotherapy, metastasis, obesity, peptide, targeting",

author = "Fei Su and Xiaoping Wang and Troy Pearson and Jangsoon Lee and Savitri Krishnamurthy and Ueno, {Naoto T.} and Kolonin, {Mikhail G.}",

note = "Publisher Copyright: {\textcopyright} 2020",

year = "2020",

month = sep,

day = "25",

doi = "10.1016/j.omto.2020.08.012",

language = "English (US)",

volume = "18",

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T1 - Ablation of Stromal Cells with a Targeted Proapoptotic Peptide Suppresses Cancer Chemotherapy Resistance and Metastasis

AU - Su, Fei

AU - Wang, Xiaoping

AU - Pearson, Troy

AU - Lee, Jangsoon

AU - Krishnamurthy, Savitri

AU - Ueno, Naoto T.

AU - Kolonin, Mikhail G.

PY - 2020/9/25

Y1 - 2020/9/25

N2 - This study improves our understanding of how tumor stromal cells recruited from fat tissue stimulate carcinoma progression to chemotherapy resistance and metastasis. A combination of chemotherapy and experimental pharmacological adipose stromal cell ablation reduced the metastatic burden in mouse models, hence establishing a new approach to cancer treatment.

AB - This study improves our understanding of how tumor stromal cells recruited from fat tissue stimulate carcinoma progression to chemotherapy resistance and metastasis. A combination of chemotherapy and experimental pharmacological adipose stromal cell ablation reduced the metastatic burden in mouse models, hence establishing a new approach to cancer treatment.

KW - EMT

KW - adipose stromal cell

KW - breast

KW - cancer

KW - cancer fibroblast

KW - chemotherapy

KW - metastasis

KW - obesity

KW - peptide

KW - targeting

UR - http://www.scopus.com/inward/record.url?scp=85090744536&partnerID=8YFLogxK

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DO - 10.1016/j.omto.2020.08.012

M3 - Article

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AN - SCOPUS:85090744536

SN - 2372-7705

VL - 18

SP - 579

EP - 586

JO - Molecular Therapy Oncolytics

JF - Molecular Therapy Oncolytics

ER -

Ablation of Stromal Cells with a Targeted Proapoptotic Peptide Suppresses Cancer Chemotherapy Resistance and Metastasis

Abstract

Keywords

ASJC Scopus subject areas

MD Anderson CCSG core facilities

Access to Document

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