Ablation of Stromal Cells with a Targeted Proapoptotic Peptide Suppresses Cancer Chemotherapy Resistance and Metastasis

Fei Su, Xiaoping Wang, Troy Pearson, Jangsoon Lee, Savitri Krishnamurthy, Naoto T. Ueno, Mikhail G. Kolonin

Research output: Contribution to journalArticle

Abstract

This study improves our understanding of how tumor stromal cells recruited from fat tissue stimulate carcinoma progression to chemotherapy resistance and metastasis. A combination of chemotherapy and experimental pharmacological adipose stromal cell ablation reduced the metastatic burden in mouse models, hence establishing a new approach to cancer treatment.

Original languageEnglish (US)
Pages (from-to)579-586
Number of pages8
JournalMolecular Therapy - Oncolytics
Volume18
DOIs
StatePublished - Sep 25 2020

Keywords

  • EMT
  • adipose stromal cell
  • breast
  • cancer
  • cancer fibroblast
  • chemotherapy
  • metastasis
  • obesity
  • peptide
  • targeting

ASJC Scopus subject areas

  • Molecular Medicine
  • Oncology
  • Cancer Research
  • Pharmacology (medical)

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