Abrogation of metastatic properties of tumour cells by de novo expression of H-2K antigens following H-2 gene transfection

R. Wallich, N. Bulbuc, G. J. Hämmerling, S. Katzav, S. Segal, M. Feldman

Research output: Contribution to journalArticle

345 Citations (Scopus)

Abstract

H-2 gene transfection was used to restore expression of H-2K antigens in metastatic and non-metastatic subclones of a murine fibrosarcoma that lack their major histocompatibility complex-encoded H-2K antigens. De novo expression of H-2K reduced tumorigenicity and abolished the formation of metastasis in syngeneic mice. Expression of H-2K may lead to effective recognition of the disseminating tumour cells by the host immune system.

Original languageEnglish (US)
Pages (from-to)301-305
Number of pages5
JournalNature
Volume315
Issue number6017
DOIs
StatePublished - Dec 1 1985

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Transfection
Fibrosarcoma
Major Histocompatibility Complex
Genes
Immune System
Neoplasms
Neoplasm Metastasis
H antigen

ASJC Scopus subject areas

  • General

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Abrogation of metastatic properties of tumour cells by de novo expression of H-2K antigens following H-2 gene transfection. / Wallich, R.; Bulbuc, N.; Hämmerling, G. J.; Katzav, S.; Segal, S.; Feldman, M.

In: Nature, Vol. 315, No. 6017, 01.12.1985, p. 301-305.

Research output: Contribution to journalArticle

Wallich, R. ; Bulbuc, N. ; Hämmerling, G. J. ; Katzav, S. ; Segal, S. ; Feldman, M. / Abrogation of metastatic properties of tumour cells by de novo expression of H-2K antigens following H-2 gene transfection. In: Nature. 1985 ; Vol. 315, No. 6017. pp. 301-305.
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