Absence of G209A and G88C mutations in the alpha-synuclein gene of Parkinson's disease in a Chinese population

Juei Jueng Lin, Kuo Chu Yueh, Dar Cheng Chang, Shinn-Zong Lin

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17 Citations (Scopus)

Abstract

A G209A mutation in the α-synuclein gene was recently discovered in a large Italian kindred and three unrelated Greek kindreds with autosomal dominant Parkinson's disease (PD). Subsequently, another mutation in the gene (G88C) was also identified in a German family with autosomal PD. These results indicate that the α-synuclein gene may have an important role in the pathogenesis of PD. This study was designed to screen the existence of both mutations of the α-synuclein gene among 100 Chinese patients with PD, including 80 with sporadic and 20 with familial PD. Results showed that none of our patients, both sporadic and familial PD, had either of the two mutations of this gene. We therefore conclude that although of great interest, these two mutations are not relevant for the pathogenesis of PD in a Han Chinese population.

Original languageEnglish (US)
Pages (from-to)217-220
Number of pages4
JournalEuropean Neurology
Volume42
Issue number4
DOIs
StatePublished - Jan 1 1999

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alpha-Synuclein
Parkinson Disease
Synucleins
Mutation
Population
Genes

Keywords

  • Alpha-synuclein gene
  • Chinese
  • Genetic mutation
  • Parkinson's disease
  • Pathogenesis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Absence of G209A and G88C mutations in the alpha-synuclein gene of Parkinson's disease in a Chinese population. / Lin, Juei Jueng; Yueh, Kuo Chu; Chang, Dar Cheng; Lin, Shinn-Zong.

In: European Neurology, Vol. 42, No. 4, 01.01.1999, p. 217-220.

Research output: Contribution to journalArticle

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