TY - GEN
T1 - Acoustic radiation force impulse imaging of cardiac tissue
AU - Trahey, Gregg E.
AU - Dahl, Jeremy J.
AU - Hsu, Stephen J.
AU - Dumont, Douglas M.
AU - Bouchard, Richard R.
AU - Eyerly, Stephanie A.
AU - Wolf, Patrick D.
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2009
Y1 - 2009
N2 - Cardiovascular disease remains the most likely cause of death in developed countries, accounting for approximately 870,000 deaths in the United States alone in 2004. Virtually every form of cardiovascular disease involves modifications in tissue stiffness. Acoustic radiation force impulse (ARFI) imaging shows great promise in the regional characterization of tissue stiffness in a variety of clinical applications. Cardiovascular tissues present unique challenges to ARFI imaging because of their dynamic changes in stiffness, high-amplitude physiological motion, and elevated stiffness levels compared to other tissues. We have implemented ARFI and shear wave elasticity imaging (SWEI) on a commercially available scanner. These imaging methods were employed on: canine and ovine heart models. Myocardial stiffness measurements were obtained throughout the cardiac cycle and with various manipulations of tissue status (ie: radiofrequency ablation,myocardial ischemia, and heart rate) under epicardial and transthoracic imaging conditions. ARFI imaging resolution was similar to corresponding B-mode images. The ARFI-induced displacement and recovery curves exhibited cyclic variations that reflected the expected changes in stiffness through the cardiac cycle. Shear wave velocimetry was successfully implemented. Also, ARFI imaging was capable of visualizing changes in myocardial stiffness due to the presence of a radiofrequency ablation-created lesion, varying heart rates, and acute myocardial ischemia. A parametric pressure-volume and ARFI imaging analysis also suggests that ARFI imaging provides unique and previously unavailable information into myocardial performance and function.
AB - Cardiovascular disease remains the most likely cause of death in developed countries, accounting for approximately 870,000 deaths in the United States alone in 2004. Virtually every form of cardiovascular disease involves modifications in tissue stiffness. Acoustic radiation force impulse (ARFI) imaging shows great promise in the regional characterization of tissue stiffness in a variety of clinical applications. Cardiovascular tissues present unique challenges to ARFI imaging because of their dynamic changes in stiffness, high-amplitude physiological motion, and elevated stiffness levels compared to other tissues. We have implemented ARFI and shear wave elasticity imaging (SWEI) on a commercially available scanner. These imaging methods were employed on: canine and ovine heart models. Myocardial stiffness measurements were obtained throughout the cardiac cycle and with various manipulations of tissue status (ie: radiofrequency ablation,myocardial ischemia, and heart rate) under epicardial and transthoracic imaging conditions. ARFI imaging resolution was similar to corresponding B-mode images. The ARFI-induced displacement and recovery curves exhibited cyclic variations that reflected the expected changes in stiffness through the cardiac cycle. Shear wave velocimetry was successfully implemented. Also, ARFI imaging was capable of visualizing changes in myocardial stiffness due to the presence of a radiofrequency ablation-created lesion, varying heart rates, and acute myocardial ischemia. A parametric pressure-volume and ARFI imaging analysis also suggests that ARFI imaging provides unique and previously unavailable information into myocardial performance and function.
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U2 - 10.1109/ULTSYM.2009.5441931
DO - 10.1109/ULTSYM.2009.5441931
M3 - Conference contribution
AN - SCOPUS:77952868568
SN - 9781424443895
T3 - Proceedings - IEEE Ultrasonics Symposium
SP - 163
EP - 168
BT - 2009 IEEE International Ultrasonics Symposium and Short Courses, IUS 2009
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2009 IEEE International Ultrasonics Symposium, IUS 2009
Y2 - 20 September 2009 through 23 September 2009
ER -