Acquired amegakaryocytic thrombocytopenia and red cell aplasia in a patient with thymoma progressing to aplastic anemia successfully treated with allogenic stem cell transplantation

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10 Scopus citations

Abstract

Association of pure red-cell aplasia with thymoma is well documented. However, acquired amegakaryocytic thrombocytopenia (AAMT) has been rarely associated with thymoma with only five reported cases in literature. We report a patient with thymoma complicated by pure red cell aplasia (PRCA) and AAMT who progressed to develop aplastic anemia (AA). The patient was refractory to 10-months of immunosuppressive therapy with cyclosporine, prednisone, and antithymocyte globulin. She was eventually treated with allogeneic stem cell transplantation (allo-SCT). On Day +323 the patient continues to be transfusion-independent. This case illustrates how in patients with thymoma and AAMT may herald development of AA. This is also the first report of a patient with AAMT progressing to thymoma-associated AA being successfully treated with allo-SCT. The successful outcome suggests allo-SCT as a feasible option similar to other AA patients.

Original languageEnglish (US)
Pages (from-to)115-118
Number of pages4
JournalHematology/ Oncology and Stem Cell Therapy
Volume12
Issue number2
DOIs
StatePublished - Jun 2019

Keywords

  • Acquired amegakaryocytic thrombocytopenia
  • Aplastic anemia
  • Red cell aplasiastem cell transplantation
  • Thymoma

ASJC Scopus subject areas

  • Hematology
  • Oncology

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