Abstract
Association of pure red-cell aplasia with thymoma is well documented. However, acquired amegakaryocytic thrombocytopenia (AAMT) has been rarely associated with thymoma with only five reported cases in literature. We report a patient with thymoma complicated by pure red cell aplasia (PRCA) and AAMT who progressed to develop aplastic anemia (AA). The patient was refractory to 10-months of immunosuppressive therapy with cyclosporine, prednisone, and antithymocyte globulin. She was eventually treated with allogeneic stem cell transplantation (allo-SCT). On Day +323 the patient continues to be transfusion-independent. This case illustrates how in patients with thymoma and AAMT may herald development of AA. This is also the first report of a patient with AAMT progressing to thymoma-associated AA being successfully treated with allo-SCT. The successful outcome suggests allo-SCT as a feasible option similar to other AA patients.
Original language | English (US) |
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Pages (from-to) | 115-118 |
Number of pages | 4 |
Journal | Hematology/ Oncology and Stem Cell Therapy |
Volume | 12 |
Issue number | 2 |
DOIs | |
State | Published - Jun 2019 |
Keywords
- Acquired amegakaryocytic thrombocytopenia
- Aplastic anemia
- Red cell aplasiastem cell transplantation
- Thymoma
ASJC Scopus subject areas
- Hematology
- Oncology