Activation of big MAP kinase 1 (BMK1/ERK5) inhibits cardiac injury after myocardial ischemia and reperfusion

Scott J. Cameron, Seigo Itoh, Christopher P. Baines, Changxi Zhang, Shinsuke Ohta, Wenyi Che, Michael Glassman, Jiing Dwan Lee, Chen Yan, Jay Yang, Jun-ichi Abe

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Big MAP kinase 1 (BMK1/ERK5) plays a critical role in pre-natal development of the cardiovascular system and post-natal eccentric hypertrophy of the heart. Of the two isoforms upstream of MAPK-kinase 5 (MEK5) known to exist, only the longer MEK5α isoform potently activates BMK1. We generated cardiac-specific constitutively active form of the MEK5α (CA-MEK5α transgenic (Tg) mice), and observed a 3 to 4-fold increase in endogenous BMK1 activation and hyperphosphorylation of connexin 43 in the ventricles of the Tg compared to wild-type mice. The CA-MEK5α-Tg-mice demonstrated a profoundly accelerated recovery of left ventricular developed pressure after ischemia/reperfusion. We propose a novel role for BMK1 in protecting the heart from ischemia/reperfusion-induced cardiac injury.

Original languageEnglish (US)
Pages (from-to)255-260
Number of pages6
JournalFEBS Letters
Volume566
Issue number1-3
DOIs
StatePublished - May 21 2004

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Mitogen-Activated Protein Kinase 7
Myocardial Reperfusion
Transgenic Mice
Reperfusion
Myocardial Ischemia
Protein Isoforms
Ischemia
Chemical activation
Cardiovascular system
Connexin 43
Wounds and Injuries
Cardiomegaly
Ventricular Pressure
Cardiovascular System
Recovery

Keywords

  • Big MAP kinase 1
  • Cardiac physiology
  • Hypoxia/reperfusion-injury
  • MAP kinase
  • MAPK-kinase 5
  • Transgenic

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Activation of big MAP kinase 1 (BMK1/ERK5) inhibits cardiac injury after myocardial ischemia and reperfusion. / Cameron, Scott J.; Itoh, Seigo; Baines, Christopher P.; Zhang, Changxi; Ohta, Shinsuke; Che, Wenyi; Glassman, Michael; Lee, Jiing Dwan; Yan, Chen; Yang, Jay; Abe, Jun-ichi.

In: FEBS Letters, Vol. 566, No. 1-3, 21.05.2004, p. 255-260.

Research output: Contribution to journalArticle

Cameron, SJ, Itoh, S, Baines, CP, Zhang, C, Ohta, S, Che, W, Glassman, M, Lee, JD, Yan, C, Yang, J & Abe, J 2004, 'Activation of big MAP kinase 1 (BMK1/ERK5) inhibits cardiac injury after myocardial ischemia and reperfusion', FEBS Letters, vol. 566, no. 1-3, pp. 255-260. https://doi.org/10.1016/j.febslet.2004.03.120
Cameron, Scott J. ; Itoh, Seigo ; Baines, Christopher P. ; Zhang, Changxi ; Ohta, Shinsuke ; Che, Wenyi ; Glassman, Michael ; Lee, Jiing Dwan ; Yan, Chen ; Yang, Jay ; Abe, Jun-ichi. / Activation of big MAP kinase 1 (BMK1/ERK5) inhibits cardiac injury after myocardial ischemia and reperfusion. In: FEBS Letters. 2004 ; Vol. 566, No. 1-3. pp. 255-260.
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