Acupuncture-Analgesia-Mediated Alleviation of Central Sensitization

Hsiang Chun Lai, Yi Wen Lin, Ching-Liang Hsieh

Research output: Contribution to journalReview article

Abstract

Pain can trigger central amplification called central sensitization, which ultimately results in hyperalgesia and/or allodynia. Many reports have showed acupuncture has an analgesic effect. We searched the related article on PubMed database and Cochrane database to discover central sensitization pathway in acupuncture analgesia. We summarized that acupuncture enhances the descending inhibitory effect and modulates the feeling of pain, thus modifying central sensitization. The possible mechanisms underlying the analgesic effects of acupuncture include segmental inhibition and the activation of the endogenous opioid, adrenergic, 5-hydroxytryptamine, and N-methyl-D-aspartic acid, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/kainate pathways. Moreover, acupuncture can locally reduce the levels of inflammatory mediators. In clinical settings, acupuncture can be used to treat headache, neuropathic pain, low back pain, osteoarthritis, and irritable bowel syndrome. These mechanisms of acupuncture analgesia may be involved in the alleviation of central sensitization.

Original languageEnglish (US)
Article number6173412
JournalEvidence-based Complementary and Alternative Medicine
Volume2019
DOIs
StatePublished - Jan 1 2019

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Acupuncture Analgesia
Central Nervous System Sensitization
Acupuncture
Hyperalgesia
Analgesics
Databases
Pain
Irritable Bowel Syndrome
Kainic Acid
Neuralgia
N-Methylaspartate
Low Back Pain
PubMed
Osteoarthritis
Adrenergic Agents
Opioid Analgesics
Headache
Serotonin
Emotions
Acids

ASJC Scopus subject areas

  • Complementary and alternative medicine

Cite this

Acupuncture-Analgesia-Mediated Alleviation of Central Sensitization. / Lai, Hsiang Chun; Lin, Yi Wen; Hsieh, Ching-Liang.

In: Evidence-based Complementary and Alternative Medicine, Vol. 2019, 6173412, 01.01.2019.

Research output: Contribution to journalReview article

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