Acute Epstein-Barr virus infection presenting as severe gastroenteritis without infectious mononucleosis-like manifestations

Mikio Fujiwara, Shin'Ichi Miyamoto, Kouta Iguchi, Toshihiro Matsunaka, Hiromi Sakashita, Tatsuaki Tsuruyama, Hirokazu Kanegane, Hiroyuki Marusawa, Hiroshi Nakase, Tsutomu Chiba

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    2 Scopus citations

    Abstract

    Primary Epstein-Barr virus (EBV) infection is usually a self-limiting disease. Although it is sometimes accompanied by severe complications such as thrombocytopenia, hemolytic anemia, and splenic rupture, predominantly gastrointestinal complications are rarely reported. We studied an unusual case of primary EBV infection associated with severe hemorrhagic gastroenteritis. EBV infection was confirmed in the biopsy specimen by demonstrating the presence of EBV DNA by polymerase chain reaction, and of EBV-encoded small RNA (EBER)-positive cells by in-situ hybridization. Our patient was suspected of having primary EBV infection from the serological findings-EBV-viral capsid antigen IgM (+) and EBV nuclear antigen (-)-but he did not show typical clinical features of infectious mononucleosis such as lymph node swelling, pharyngitis, liver dysfunction, and splenomegaly. A definite diagnosis of primary EBV infection was made using biopsy specimens by demonstrating the presence of EBV DNA and EBER-positive cells.

    Original languageEnglish (US)
    Pages (from-to)398-403
    Number of pages6
    JournalClinical Journal of Gastroenterology
    Volume2
    Issue number6
    DOIs
    StatePublished - Dec 1 2009

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    Keywords

    • EBV-encoded early small RNA
    • Epstein-Barr virus
    • Gastroenteritis
    • Polymerase chain reaction

    ASJC Scopus subject areas

    • Gastroenterology

    Cite this

    Fujiwara, M., Miyamoto, SI., Iguchi, K., Matsunaka, T., Sakashita, H., Tsuruyama, T., Kanegane, H., Marusawa, H., Nakase, H., & Chiba, T. (2009). Acute Epstein-Barr virus infection presenting as severe gastroenteritis without infectious mononucleosis-like manifestations. Clinical Journal of Gastroenterology, 2(6), 398-403. https://doi.org/10.1007/s12328-009-0114-8