Acute lymphoblastic leukemia with Burkitt-like morphologic features and high myeloperoxidase activity

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Expression of a high level of myeloperoxidase (MPO) as a sole myeloid marker in acute leukemias that express typical lymphoblastic markers is unusual. Herein we report 5 cases of MPO+, otherwise typical acute lymphoblastic leukemia (ALL) without the expression of other myeloid markers. In most cases, MPO positivity was detected in more than 20% of blasts by immunologic (flow cytometric) and enzymatic testing. The striking feature of most of these cases is a morphologic picture reminiscent of that seen in Burkitt-like B-cell ALL with basophilic cytoplasm and vacuoles but no expression of surface immunoglobulin. All cases responded to ALL therapy and should be distinguished from myeloid leukemia and from Burkitt leukemia/lymphoma.

Original languageEnglish (US)
Pages (from-to)182-185
Number of pages4
JournalAmerican journal of clinical pathology
Volume132
Issue number2
DOIs
StatePublished - Aug 1 2009

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Precursor Cell Lymphoblastic Leukemia-Lymphoma
Peroxidase
Burkitt Lymphoma
B-Cell Antigen Receptors
Myeloid Leukemia
Vacuoles
Cytoplasm
Leukemia
B-Lymphocytes
Therapeutics

Keywords

  • Acute lymphoblastic leukemia
  • Burkitt
  • Mixed lineage
  • Myeloperoxidase
  • Therapy

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Acute lymphoblastic leukemia with Burkitt-like morphologic features and high myeloperoxidase activity. / Rytting, Michael E.; Kantarjian, Hagop; Albitar, Maher.

In: American journal of clinical pathology, Vol. 132, No. 2, 01.08.2009, p. 182-185.

Research output: Contribution to journalArticle

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