Abstract
Adaptive immunity involves antigen-specific responses which are highly adapted to the specific pathogen and firmly regulated by crosstalk between innate immune cells. It has evolved to provide a versatile and finely tuned repertoire of receptors which can discriminate between self- and nonself-antigens. During the development, immature B and T lymphocytes undergo antigen receptor gene rearrangements to create an enormously diverse repertoire containing a set of antigen-specific receptors capable of recognizing all potential antigens. After pathogen elimination and cellular contraction, pathogen-specific long-lived memory lymphocytes are generated. These memory lymphocytes rapidly and strongly respond to subsequent encounter with the invading pathogen and generate new effector cells to eliminate the pathogen.
| Original language | English (US) |
|---|---|
| Title of host publication | Encyclopedia of Infection and Immunity |
| Subtitle of host publication | Volumes 1-4 |
| Publisher | Elsevier |
| Pages | V1-39-V1-55 |
| Volume | 1 |
| ISBN (Electronic) | 9780323903035 |
| ISBN (Print) | 9780128187319 |
| DOIs | |
| State | Published - Jan 1 2022 |
| Externally published | Yes |
Keywords
- Adaptive immunity
- Antibody-mediated immunity
- B cell activation
- B cell development
- B cell subsets
- Cell-mediated immunity
- Endogenous antigens
- Exogenous antigens
- Immunological memory
- Receptor diversity
- Somatic DNA rearrangement
- T cell activation
- T cell subsets
- T-dependent antigens
- T-independent antigens
ASJC Scopus subject areas
- General Immunology and Microbiology
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