Abstract
Patients with early-stage nodal follicular lymphoma (FL) may be rendered free of detectable disease by a diagnostic excisional biopsy. We reviewed the management and outcomes of 48 patients with FL, diagnosed from 2003–2013, treated at a single institution. The primary endpoints were local control (LC) and progression-free survival (PFS). Median age at diagnosis was 54.5 years (range 15–74 years). Forty-seven patients were stage I (97.9%); 15 patients (31.3%) had grade 3 disease. Initial management consisted of observation (12 patients; 25.0%), radiation therapy (RT) alone (12 patients; 25.0%), systemic therapy alone (9 cases; 18.8%), or both (15 patients; 31.3%). Median follow-up was 4.92 years (range 0.5–13.83 years). 4-year PFS and OS were 80.9% and 97.1%, respectively. Patients treated with additional therapy experienced significantly better 4-year LC (100% vs. 81.8%; p =.012) and 4-year PFS (86.7% vs. 63.6%; p =.006). Patients with completely resected limited-stage FL would benefit from therapy beyond excisional biopsy alone.
Original language | English (US) |
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Pages (from-to) | 3258-3265 |
Number of pages | 8 |
Journal | Leukemia and Lymphoma |
Volume | 60 |
Issue number | 13 |
DOIs | |
State | Published - Nov 10 2019 |
Keywords
- Early-stage follicular lymphoma
- completely resected nodal follicular lymphoma
- excisional biopsy
- nodal follicular lymphoma
- radiation therapy
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research