Addressing Common Pain Syndromes in Pediatric Stem Cell Transplant: A Review

Avis Harden, Kimberly Kresta, Nelda Itzep

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Assessment and management of pain for pediatric patients receiving stem cell transplants can be challenging for a health care team. Diagnostic evaluation and interventions vary between institutions and individual provider practices. In this review, we investigate and describe approaches to pain management for the most common sources of pain in pediatric patients undergoing stem cell transplants. Mucositis pain, abdominal pain, and hemorrhagic cystitis emerged as the most frequent sources of acute pain in children during conditioning and transplantation periods. Furthermore, psychosocial distress and psychological pain or distress constitute significant components of the total pain experienced by children undergoing stem cell transplantation. We will expand upon appropriate usage and escalation of opioids, as well as complementary interventions and timely initiation of interventions, in order to help control pain in these clinical syndromes.

Original languageEnglish (US)
Article number139
Issue number2
StatePublished - Feb 2022


  • Mucositis
  • Pain
  • Palliative
  • Stem cell transplant

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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