Adiponectin receptor-mediated signaling ameliorates cerebral cell damage and regulates the neurogenesis of neural stem cells at high glucose concentrations: An in vivo and in vitro study

J. Song, S. M. Kang, E. Kim, C. H. Kim, Ho-Taek Song, J. E. Lee

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15 Citations (Scopus)

Abstract

In the central nervous system (CNS), hyperglycemia leads to neuronal damage and cognitive decline. Recent research has focused on revealing alterations in the brain in hyperglycemia and finding therapeutic solutions for alleviating the hyperglycemia-induced cognitive dysfunction. Adiponectin is a protein hormone with a major regulatory role in diabetes and obesity; however, its role in the CNS has not been studied yet. Although the presence of adiponectin receptors has been reported in the CNS, adiponectin receptor-mediated signaling in the CNS has not been investigated. In the present study, we investigated adiponectin receptor (AdipoR)-mediated signaling in vivo using a high-fat diet and in vitro using neural stem cells (NSCs). We showed that AdipoR1 protects cell damage and synaptic dysfunction in the mouse brain in hyperglycemia. At high glucose concentrations in vitro, AdipoR1 regulated the survival of NSCs through the p53/p21 pathway and the proliferation- and differentiation-related factors of NSCs via tailless (TLX). Hence, we suggest that further investigations are necessary to understand the cerebral AdipoR1-mediated signaling in hyperglycemic conditions, because the modulation of AdipoR1 might alleviate hyperglycemia-induced neuropathogenesis.

Original languageEnglish (US)
Article numbere1844
JournalCell Death and Disease
Volume6
DOIs
StatePublished - Aug 6 2015

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Adiponectin Receptors
Neural Stem Cells
Neurogenesis
Hyperglycemia
Glucose
Central Nervous System
Adiponectin
Brain
High Fat Diet
Obesity
In Vitro Techniques
Hormones
Research
Proteins

ASJC Scopus subject areas

  • Immunology
  • Cellular and Molecular Neuroscience
  • Cell Biology
  • Cancer Research

Cite this

Adiponectin receptor-mediated signaling ameliorates cerebral cell damage and regulates the neurogenesis of neural stem cells at high glucose concentrations : An in vivo and in vitro study. / Song, J.; Kang, S. M.; Kim, E.; Kim, C. H.; Song, Ho-Taek; Lee, J. E.

In: Cell Death and Disease, Vol. 6, e1844, 06.08.2015.

Research output: Contribution to journalArticle

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