Adjuvant hepatic arterial infusional chemotherapy with 5-fluorouracil and cisplatin after curative resection of hepatocellular carcinoma

Do Young Kim, Sang Hoon Ahn, Seung Up Kim, Sae Byeol Choi, Kwang Hun Lee, Mi Sook Park, Jun Yong Park, Do Yun Lee, Kwang Hyub Han, Kyung Sik Kim

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    Abstract

    Objectives: We investigated whether adjuvant hepatic arterial infusional chemotherapy (HAIC) with 5-fluorouracil (5-FU) and cisplatin reduces the recurrence of hepatocellular carcinoma (HCC) after curative resection. Methods: Between January 2006 and December 2008, 31 HCC patients received four cycles of adjuvant HAIC with 5-FU and cisplatin via port system after curative resection. During the same period, 62 patients, who did not take any adjuvant therapy, were selected as controls. Results: Tumor characteristics, such as distribution of TNM stage, pathologic differentiation, portal vein invasion, or microscopic invasion did not differ between control and adjuvant groups. During follow-up, recurrence developed in 11 adjuvant (35.5%) and 24 control patients (38.7%; p = 0.823). Tumor progression after recurrence was the cause of death in 2 adjuvant (28.6%) and 7 control patients (38.8%; p = 0.912). The 2-year recurrence rate was 9.1% in the adjuvant group and 4.2% in the control group, with the median recurrence-free survival time being 10.5 and 7.5 months, respectively (p = 0.324). The 3-year cumulative survival rate was 73.3% in the adjuvant group and 68.3% in the control group (p = 0.355). Conclusion: Adjuvant HAIC with 5-FU and cisplatin did not offer any beneficial effect on the recurrence after curative resection of HCC.

    Original languageEnglish (US)
    Pages (from-to)184-191
    Number of pages8
    JournalOncology
    Volume81
    Issue number3-4
    DOIs
    StatePublished - Dec 1 2011

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    Keywords

    • Adjuvant therapy
    • Hepatic arterial infusional chemotherapy
    • Hepatocellular carcinoma

    ASJC Scopus subject areas

    • Oncology
    • Cancer Research

    Cite this

    Kim, D. Y., Ahn, S. H., Kim, S. U., Choi, S. B., Lee, K. H., Park, M. S., Park, J. Y., Lee, D. Y., Han, K. H., & Kim, K. S. (2011). Adjuvant hepatic arterial infusional chemotherapy with 5-fluorouracil and cisplatin after curative resection of hepatocellular carcinoma. Oncology, 81(3-4), 184-191. https://doi.org/10.1159/000333827