Adult Primary Brain Neoplasm, Including 2016 World Health Organization Classification

Kevin Yuqi Wang, Melissa M. Chen, Christie M. Malayil Lincoln

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


In 2016, the World Health Organization (WHO) central nervous system (CNS) classification scheme incorporated molecular parameters in addition to traditional microscopic features for the first time. Molecular markers add a level of objectivity that was previously missing for tumor categories heavily dependent on microscopic observation for pathologic diagnosis. This article provides a brief discussion of the major 2016 updates to the WHO CNS classification scheme and reviews typical MR imaging findings of adult primary CNS neoplasms, including diffuse infiltrating gliomas, ependymal tumors, neuronal/glioneuronal tumors, pineal gland tumors, meningiomas, nerve sheath tumors, solitary fibrous tumors, and lymphoma.

Original languageEnglish (US)
Pages (from-to)121-138
Number of pages18
JournalNeuroimaging Clinics of North America
Issue number1
StatePublished - Feb 2021


  • Adult primary neoplasm
  • Central nervous system
  • MR imaging
  • WHO

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

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